Vascular Risk Factors and Risk for Alzheimer’s Disease and Mild Cognitive Impairment: Population-Based Studies

  • Hilkka Soininen
  • Miia Kivipelto
  • Aulikki Nissinen
Part of the Advances in Behavioral Biology book series (ABBI, volume 57)


Mild Cognitive Impairment Vascular Risk Factor High Systolic Blood Pressure Healthy Elderly Subject High Serum Total Cholesterol 
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  1. 1.
    Brookmeyer R, Gray S, Kawas C (1998) Projections of Alzheimer’s disease in the United States and the public health impact of delaying disease onset. Am J Public Health 88:1337–1342PubMedCrossRefGoogle Scholar
  2. 2.
    Kivipelto M, Helkala EL, Hänninen T, et al (2001a) Midlife vascular risk factors and late-life mild cognitive impairment: a population based study. Neurology 56:1683–1689Google Scholar
  3. 3.
    Petersen RC, Smith GE, Ivnik RJ, et al (1995) Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. JAMA 273:1274–1278PubMedCrossRefGoogle Scholar
  4. 4.
    Tervo S, Kivipelto M, Hänninen T, et al (2004) Incidence and risk factors for mild cognitive impairment: a population-based three year follow-up study of cognitively healthy elderly subjects. Dement Geriatr Cogn Disord 17:96–203CrossRefGoogle Scholar
  5. 5.
    Kivipelto M, Helkala EL, Laakso MP, et al. (2001b) Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population-based study. BMJ 322:1447–1451CrossRefGoogle Scholar
  6. 6.
    Kivipelto M, Helkala EL, Laakso MP, et al (2002a) Apolipoprotein E ε4 allele, elevated midlife cholesterol and systolic blood pressure are independent risk factors for late-life Alzheimer’s disease. Ann Intern Med 137:149–155Google Scholar
  7. 7.
    Kivipelto M, Helkala EL, Nissinen A, et al (2002b) Vascular risk factors, ApoE ε4 allele and gender and the risk of Alzheimer’s disease: perspectives on prevention. Drug Dev Res 56:85–94CrossRefGoogle Scholar
  8. 8.
    Kivipelto M, Anttila T, Fratiglioni L, et al (2005) Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer’s disease. Arch Neurol 62:1556–1560PubMedCrossRefGoogle Scholar
  9. 9.
    Anttila T, Helkala EL, Viitanen M, et al. (2004) Alcohol drinking at midlife and the risk of mild cognitive impairment and dementia in late-life: a population-based study. BMJ 329:539–542PubMedCrossRefGoogle Scholar
  10. 10.
    Kivipelto M, Laakso MP, Tuomilehto J, et al (2002c) Hypertension and hypercholesterolemia as risk factors for Alzheimer's disease: potential for pharmacological intervention. CNS Drugs 16:435–444.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Hilkka Soininen
    • 1
  • Miia Kivipelto
  • Aulikki Nissinen
  1. 1.Department of NeurologyUniversity of KuopioFinland

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