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Sulphur Colloid for Imaging Lymph Nodes and Bone Marrow

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Nanoparticles in Biomedical Imaging

Part of the book series: Fundamental Biomedical Technologies ((FBMT,volume 102))

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Abstract

99mTechnetium sulphur colloid (TcSC) has become very widely used since the advent of lymphoscintigraphy (LS) in the late 1970s and, especially, sentinel lymph node biopsy (SLNB) in 1992. This colloid provides very good external imaging of lymph node drainage patterns in oncology patients. Moreover, this radiocolloid’s in vivo kinetics and relative time-independence make it an excellent agent for localizing sentinel lymph nodes in the operating room. SLNB is well on its way to becoming the standard of care for surgical lymph node staging in melanoma and breast cancer and is being investigated in a variety of other solid tumors. Bone marrow imaging with this agent provides valuable diagnostic information in patients with blood dyscrasias and bone marrow neoplasms and those with osteomyelitis, infected orthopedic prostheses, and neuropathic pedal conditions.

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References

  • Abramova, L., Parekh, J., Irvin, W.P. Jr., et al.,2002. Sentinel node biopsy in vulvar and vaginal melanoma: presentation of six cases and a literature review. Ann Surg Oncol 9, 840–846.

    PubMed  Google Scholar 

  • Achong, D.M., Oates, E.,1995. Diffusely discordant In-111 WBC/Tc-99m SC bone marrow uptake. A possible chemotherapeutic effect. Clin Nucl Med 20, 599–600.

    PubMed  CAS  Google Scholar 

  • Albertini, J.J., Cruse, C.W., Rapaport, D., et al., 1996. Intraoperative radiolymphoscintigraphy improves sentinel node identification in patients with melanoma. Ann Surg 223, 217–224.

    PubMed  CAS  Google Scholar 

  • Albo, D., Wayne, J.D., Hunt, K.K., et al.,2001. Anaphylactic reactions to isosulfan blue during sentinel lymph node biopsy for breast cancer. Amer J Surg 182, 393–398.

    PubMed  CAS  Google Scholar 

  • Alex, J.C., Krag, D.N., 1993a. Gamma-probe guided localization of lymph nodes. Surg Oncol 2, 137–143.

    Google Scholar 

  • Alex, J.C., Krag, D.N.,1996. The gamma probe-guided resection of radiolabeled primary lymph nodes. Surg Oncol Clin North Am 5, 33–41.

    CAS  Google Scholar 

  • Alex, J.C., Krag, D.N., Harlow, S.P., Meijer, S., Loggie, B.W., Kuhn, J.A., Gadd, M., Weaver, D.L.,1998. Localization of regional lymph nodes in melanomas of the head and neck. Arch Otolaryngol Head Neck Surg 124, 135–140.

    PubMed  CAS  Google Scholar 

  • Alex, J.C., Sasaki, C.T., Krag, D.N., Wenig, B., Pyle, P.B.,2000. Sentinel lymph node radiolocalization in head and neck squamous cell carcinoma. Laryngoscope 110 (2 Pt 1), 198–203.

    PubMed  CAS  Google Scholar 

  • Alex, J.C., Weaver, D.L., Fairbanks, J.T., Rankin, B.S., Krag, D.N., 1993b. Gamma probe-guided lymph node localization in malignant melanoma. Surg Oncol 2, 303–308.

    CAS  Google Scholar 

  • Altinyollar, H., Berberoglu, U., Celen, O.,2002. Lymphatic mapping and sentinel lymph node biopsy in squamous cell carcinoma of the lower lip. Eur J Surg Oncol 28, 72–74.

    PubMed  CAS  Google Scholar 

  • Arican, P., ĂŤbis, E., Aras, G., Çam, R., KĂĽcĂĽk, N.Ă–., 2005. Identification of sentinel node in Stage I-II breast cancer with lymphoscintigraphy and surgical gamma probe: comparison of Tc-99m MIBI and Tc-99m sulphur colloid. Clin Nucl Med 30, 317–321.

    Google Scholar 

  • Ariyan, S., Ariyan, C., Farber, L.R., Fischer, D.S., Flynn, S.D., Truini, C.,2004. Reliability of identification of 655 sentinel lymph nodes in 263 consecutive patients with malignant melanoma. J Am Coll Surg 198, 924–932.

    PubMed  Google Scholar 

  • Balch, C.M., Soong, S-J., Bartolucci, A., et al.,1996. Efficacy of an elective regional lymph node dissection of 1 to 4 mm thick melanomas for patients 60 years of age or younger. Ann Surg 224, 255–266.

    PubMed  CAS  Google Scholar 

  • Balch, C.M., Soong, S-J., Gershenwald, J.E., Thompson, J.F., Reintgen, D.S., Cascinelli, N., et al., 2001a. Prognostic factors analysis in 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol 19, 3622–3634.

    CAS  Google Scholar 

  • Balch, C.M., Soong, S-J., Ross, M.I., et al.,2000. Long-term results of a multi-institutional randomized trial comparing prognostic factors and surgical results for intermediate thickness melanomas (1.0 to 4.0 mm). Ann Surg Oncol 7, 87–97.

    PubMed  CAS  Google Scholar 

  • Balch, C.M., Soong, S-J., Smith, T., et al., 2001b. Long-term results of a prospective surgical trial comparing 2 cm vs. 4 cm excision margins for 740 patients with 1–4 mm melanomas. Ann Surg Oncol 8, 101–108.

    CAS  Google Scholar 

  • Bauer, T.W., Spitz, F.R., Callans, L.S., et al.,2002. Subareolar and peritumoral injection identify similar sentinel nodes for breast cancer. Ann Surg Oncol 9, 169–172.

    PubMed  Google Scholar 

  • Bedrosian, I., Faries, M.B., GuerryDuPont, I.V., Elenitsas, R., Schuchter, L., Mick, R., etal., 2000. Incidence of sentinel node metastasis in patients with thin primary melanoma ( < 1mm) with vertical growth phase. Ann Surg Onco l7, 262–267.

    Google Scholar 

  • Berlangieri, S.U., Peters, W.P., Coleman, R.E.,1993. Distribution of 99mTc-sulphur colloid during granulocytye colony-stimulating factor administration in autologous bone marrow transplantation. Nucl Med Commun 14, 896–901.

    PubMed  CAS  Google Scholar 

  • Berman, C.G., Norman, J., Cruse, C.W., et al.,1992. Lymphoscintigraphy in malignant melanoma. Ann Plast Surg 28, 29–32.

    PubMed  CAS  Google Scholar 

  • Bilchik, A.J., Nora, D.T., Sobin, L.H., et al.,2003. Effect of lymphatic mapping on the new tumor-node-metastasis classification for colorectal cancer. J Clin Oncol 21, 668–672.

    PubMed  Google Scholar 

  • Bleicher, R.J., Essner, R., Foshag, L.J., Wanek, L.A., Morton, D.L.,2003. Role of sentinel lymphadenectomy in tin invasive melanomas. J Clin Oncol 21, 1326–1331.

    PubMed  Google Scholar 

  • Boobol, S.K., Fey, J.V., Borgen, P.I., et al.,2001. Intradermal isotope injection: a highly accurate method of lymphatic mapping in breast carcinoma. Ann Surg Oncol 8, 20–24.

    Google Scholar 

  • Borgstein, P.J., Meijer, S., Pijpers, R.1997. Intradermal blue dye to identify sentinel lymph node in breast cancer. Lancet 349, 1668–1669.

    PubMed  CAS  Google Scholar 

  • Borgstein, P.J., Meijer, S., Pijpers, R.J., van Diest, P.J.2000. Functional lymphatic anatomy for sentinel node biopsy in breast cancer. Echoes from the past and the periareolar blue method. Ann Surg 232, 81–89.

    PubMed  CAS  Google Scholar 

  • Bostick, P., Essner, R., Glass, E., Kelley, M., Sarantou, T., Foshag, L.J., et al.,1999. Comparison of blue dye and probe-assisted intraoperative lymphatic mapping in m melanoma to identify sentinel nodes in 100 lymphatic basins. Arch Surg 134, 43–49.

    PubMed  CAS  Google Scholar 

  • Bostick, P., Essner, R., Sarantou, T., Kelley, M., Glass, E., Foshag, L., Stern, S., Morton, D.1997. Intraoperative lymphatic mapping for early-stage melanoma of the head and neck. Am J Surg 174, 536–43.

    PubMed  CAS  Google Scholar 

  • Carloss, H., Winslow, D., Kastan, L., Yam, L.T., 1977. Bone marrow necrosis. Diagnosis and assessment of extent of involvement by radioisotope studies. Arch Int Med 137, 863–866.

    CAS  Google Scholar 

  • Cascinelli, N., Belli, F., Santinami, M., Fait, V., Testori, A., Ruka, W., et al.,2000. Sentinel lymph node biopsy in cutaneous melanoma: the WHO Melanoma Program experience. Ann Surg Oncol 7, 467–474.

    Google Scholar 

  • Cascinelli, N., Morabito, A., Santinami, M., et al.,1998. Immediate or delayed dissection of regional nodes in patients with melanoma of the trunk: a randomized trial. Lancet 351, 793–796.

    PubMed  CAS  Google Scholar 

  • Chao, C., Wong, S., Edwards, M.J., et al.,2003. Sentinel lymph node biopsy for head and neck melanomas. Ann Surg Oncol 10, 21–26.

    PubMed  Google Scholar 

  • Cimmino, V.M., Brown, A.C., Szocik, J.F., et al.,2001. Allergic reactions to isosulfan blue during sentinel node biopsy: a common event. Surgery 130, 439–442.

    PubMed  CAS  Google Scholar 

  • Civantos, F.J., Moffat, F.L., Goodwin, W.J.,2006. Lymphatic mapping and sentinel lymphadenectomy for 106 head and neck lesions: contrasts between oral cavity and cutaneous malignancy. Laryngoscope 116(Suppl. 109), 1–15.

    Google Scholar 

  • Civantos, F.J., Gomez, C., Duque, C., et al.,2003. Sentinel node biopsy in oral cavity cancer: correlation with PET scan and immunohistochemistry. Head Neck 25, 1–9.

    PubMed  Google Scholar 

  • Coates, G.G., Eisenberg, B., Dail, D.H.,1994. Tc-99m sulphur colloid demonstration of diffuse pulmonary interstitial extramedullary hematopoiesis in a patients with myelofibrosis. A case report and review of the literature. Clin Nucl Med 19, 1079–1084.

    PubMed  CAS  Google Scholar 

  • Cody, H.S. III, Fey, J., Akhurst, T., Fazzari, M., Mazumdar, M., Yeung, H., et al.,2001. Complementarity of blue dye and isotope in sentinel node localization for breast cancer: univariate and multivariate anĂ lisis of 966 procedures. Ann Surg Oncol 8, 13–19.

    PubMed  Google Scholar 

  • Copping, C., Dalgleish, S.M., Dudley, N.J., Griffiths, P.A., Harrington, M., Potter, R., et al.,1992. The role of 99mTc-HMPAO white cell imaging in suspected orthopaedic infection. Br J Radiol 65, 309–312.

    PubMed  CAS  Google Scholar 

  • Corsetti, R.L., Allen, H.M., Wanebo, H.J., 2003. Thin < 1mm Level II and IV melanomas are higher risk lesions for regional failure and warrant sentinel lymph node biopsy. AnnSurgOncol l7, 456–460.

    Google Scholar 

  • Cox, C.E., Bass, S.S., McCann, C.R., et al.,2000. Lymphatic mapping and sentinel lymph node biopsy in patients with breast cancer. Ann Rev Med 51, 525–542.

    PubMed  CAS  Google Scholar 

  • Datz, F.L., Taylor, A. Jr.,1985. The clinical use of radionuclide bone marrow imaging. Semin Nucl Med 15, 239–259.

    PubMed  CAS  Google Scholar 

  • De Cicco, C., Cremonesi, M., Chinol, M., et al.,1997. Optimization of axillary lymphoscintigraphy to detect the sentinel node in breast cancer. Tumori 83, 539–541.

    PubMed  Google Scholar 

  • D’Eredita, G., Giardina, C., Guerreri, A.M., Berardi, T.2006. A further validation of subareolar injection technique for breast sentinel lymph node biopsy. Ann Surg Oncol 13, 1–7.

    Google Scholar 

  • Derossis, A.M., Fey, J., Yeung, H., Yeh, S.D.J., Heerdt, A.S., Petrek, J., et al.,2001. A trend analysis of the relative value of blue dye and isotope localization in 2,000 consecutive cases of sentinel node biopsy for breast cancer. J Am Coll Surg 193, 473–478.

    PubMed  CAS  Google Scholar 

  • Desai, A.G., Thakur, M.L.,1985. Radiopharmaceuticals for spleen and bone marrow studies. Semin Nucl Med 15, 229–238.

    PubMed  CAS  Google Scholar 

  • Doubrovsky, A., De Wilt, J.H., Scolyer, R.A., McCarthy, W.H., Thompson, J.F.,2004. Sentinel node biopsy is more accurate than elective lymph node dissection in determining the regional node status of patients with cutaneous melanoma. Ann Surg Oncol 11, S122–S123.

    Google Scholar 

  • Elster, A.D., Theros, E.G., Key, L.L., Stanton, C.1992. Autosomal recessive osteopetrosis: bone marrow imaging. Radiology 182, 507–514.

    PubMed  CAS  Google Scholar 

  • Esper, I.E., Blondet, C., Moullart, V., et al.,2004. The usefulness of 99mTc sulphur colloid bone marrow scintigraphy combined with 111In leucocyte scintigraphy in prosthetic joint infection. Nucl Med Commun 25, 171–175.

    Google Scholar 

  • Essner, R., Bostick, P.J., Glass, E.C., Foshag, L.J., Haigh, P.I., Wang, H-J., Morton, D.L.,2000. Standardized probe-directed sentinel node dissection in melanoma. Surgery 127, 26–31.

    PubMed  CAS  Google Scholar 

  • Essner, R., Conforti, A., Kelley, M.C., et al.,1999. Efficacy of lymphatic mapping, sentinel lymphadenectomy and selective complete node dissection as a therapeutic procedure for early-stage melanoma. Ann Surg Oncol 6, 442–449.

    PubMed  CAS  Google Scholar 

  • Evans, H.L., Krag, D.N., Teates, C.D., Patterson, J.W., Meijer, S., Harlow, S.P., et al.,2003. Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excision. Ann Surg Oncol 10, 416–425.

    PubMed  Google Scholar 

  • Faries, M.B., Bleicher, R., Ye, X., Essner, R., Morton, D.L.,2004. Lymphatic mapping and sentinel lymphadenectomy for primary and metastatic pulmonary malignant neoplasms. Arch Surg 139, 870–877.

    PubMed  Google Scholar 

  • Fee, J.H., Robinson, D.S., Sample, W.F., et al.,1978. The determination of lymph shed by colloidal gold scanning in patients with malignant melanoma: a preliminary study. Surgery 84, 626–632.

    PubMed  CAS  Google Scholar 

  • Frier, M., Griffiths, P., Ramsey, A.,1981. The physical and chemical characteristics of sulphur colloids. Eur J Nucl Med 6, 255–260.

    PubMed  CAS  Google Scholar 

  • Galimberti, V., Zurrida, S., Zucali, P., Luini, A.,1998. Can sentinel node biopsy avoid axillary dissection in clinically node-negative breast cancer patients? The Breast 7, 8–10.

    Google Scholar 

  • Gershenwald, J.E., Colome, M.I., Lee, J.E., Mansfield, P.F., Tseng, C-h., Lee, J.J., Balch, C.M., Ross, M.I., 1998b. Patterns of recurrence following a negative sentinel lymph node biopsy in 243 patients with Stage I or II melanoma. J Clin Oncol 16, 2253–2260.

    CAS  Google Scholar 

  • Gershenwald, J.E., Mansfield, P.F., Lee, J.E., Ross, M.I., 2000. Role for lymphatic mapping and sentinel lymph node biopsy in patients with thick ( > 4mm)primary melanoma. Ann Surg Onco l7, 160–165.

    Google Scholar 

  • Gershenwald, J.E., Tseng, C-h., Thompson, W., Mansfield, P.E., Lee, J.E., Bouvet, M., Lee, J.J., Ross, M.I., 1998a. Improved sentinel lymph node localization in patients with primary melanoma with the use of radiolabeled colloid. Surgery 124, 303–310.

    Google Scholar 

  • Glass, L.F., Messina, J.L., Cruse, W., et al.,1996. The use of intraoperative radiolymphoscintigraphy for sentinel node biopsy in patients with malignant melanoma. Dermatol Surg 22, 715–720.

    PubMed  CAS  Google Scholar 

  • Godellas, C.V., Berman, C.G., Lyman, G., et al.,1995. The identification and mapping of melanoma regional nodal metastases: minimally invasive surgery for the diagnosis of nodal metastases. Amer Surg 61, 97–101.

    CAS  Google Scholar 

  • Gulec, S.A., Moffat, F.L., Carroll, R.G.,1997. The expanding clinical role for intraoperative gamma probes. In: Freeman, L.M. (Ed.). Nuclear Medicine Annual 1997. Lippincott-Raven, Philadelphia, pp. 209–237.

    Google Scholar 

  • Gulec, S.A., Moffat, F.L., Carroll, R.G., et al.,1998. Sentinel lymph node localization in early breast cancer. J Nucl Med 39, 1388–1393.

    PubMed  CAS  Google Scholar 

  • Harlow, S.P., Krag, D.N., Julian, T.B., et al.,2005. Prerandomization surgical training for the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-32 Trial. Ann Surg 241, 48–54.

    PubMed  Google Scholar 

  • Henry, R.E., Fletcher, J.W., George, E.A., Donati, R.M.,1975. Bone marrow 99mTc sulphur colloid distribution and marrow cellularity. Amer J Med Sci 270, 419–425.

    PubMed  CAS  Google Scholar 

  • Higashi, H., Natsugoe, S., Uenosono, Y., Ehi, K., Arigami, T., Nakabeppu, Y., Nakajo, M., Aikuo, T.2004. Particle size of tin and phytate colloid in sentinel node identification. J Surg Res 121, 1–4.

    PubMed  CAS  Google Scholar 

  • Hill, A.D.K., Tran, K.N., Akhurst, T., et al.,1999. Lessons learned from 500 cases of lymphatic mapping for breast cancer. Ann Surg 229, 5258–5535.

    Google Scholar 

  • Hirsch, J.I., Tirado, J., Cho, S.R., et al.,1982. Use of isosulfan blue for identification of lymphatic vessels: experimental and clinical evaluation. AJR Amer J Roentgenol 139, 1061–1064.

    CAS  Google Scholar 

  • Hoppin, E.C., Lewis, J.P., DeNardo, S.J.,1979. Bone marrow scintigraphy in the evaluation of acute nonlymphocytic leukemia. Clin Nucl Med 4, 296–301.

    PubMed  CAS  Google Scholar 

  • Hung, J.C., Wiseman, G.A., Wahner, H.W., Mullan, B.P., Taggart, T.R., Dunn, W.L.,1995. Filtered technetium 99m sulfur colloid evaluated for lymphoscintigraphy. J Nucl Med 36, 1895–1901.

    PubMed  CAS  Google Scholar 

  • Jacobs, I.A., Chang, C.K., DasGupta, T.K., Salti, G.I., 2003. Role of sentinel lymph node biopsy in patients with thin (≤1 mm) primary melanoma. Ann Surg Oncol 10, 558–561.

    PubMed  Google Scholar 

  • Jansen, L., Koops, H.S., Nieweg, O.E., Doting, M.H.E., Kapteijn, B.A.E., Balm, A.J.M., Vermey, A., et al.,2000. Sentinel node biopsy for melanoma in the head and neck region. Head Neck 22, 27–33.

    PubMed  CAS  Google Scholar 

  • Kahn, C.E., Jr., Ryan, J.W., Hatfield, M.K., Martin, W.B.,1988. Combined bone marrow and gallium imaging. Differentiation of osteomyelitis and infarction in sickle hemoglobinopathy. Clin Nucl Med 13, 443–449.

    PubMed  Google Scholar 

  • Kirkwood, J.M., Strawderman, M.H., Ernsthoff, M.S., etal., 1996. Interferon α_2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial 1684. J Clin Oncol 14, 7–17.

    PubMed  CAS  Google Scholar 

  • Klimberg, V.S., Rubio, I.T., Henry, R., et al.,1999. Subareolar versus peritumoral injection for location of the sentinel lymph node. Ann Surg 229, 860–865.

    PubMed  CAS  Google Scholar 

  • Kloiber, R., Damtew, B., Rosenthall, L.,1981. A crossover study comparing the effect of particle size on the distribution of radiocolloid in patients. Clin Nucl Med 6, 204–206.

    PubMed  CAS  Google Scholar 

  • Kniseley, R.M., Andrews, G.A., Tanida, R., Edwards, C.L., Kyker, G.C.,1966. Delineation of active marrow by wholebody scanning with radioactive colloids. J Nucl Med 575, 582.

    Google Scholar 

  • Krag, D.N., Weaver, D.L., Alex, J.C., Fairbank, J.T.,1993. Surgical resection and radiolocalization of the sentinel node in breast cancer using a gamma probe. Surg Oncol 2, 335–340.

    PubMed  CAS  Google Scholar 

  • Krag, D.N., 1998a. Minimal access surgery for staging regional lymph nodes: the sentinel node concept. Curr Probl Surg 35, 951–1018.

    CAS  Google Scholar 

  • Krag, D.N.,1999. Current status of sentinel lymph node surgery for breast cancer. J Natl Cancer Inst 91, 302–304.

    PubMed  CAS  Google Scholar 

  • Krag, D.N., Ashikaga, T., Harlow, S.P., Weaver, D.L., 1998b. Development of sentinel node targeting technique in breast cancer patients. Breast J 4, 67–74.

    Google Scholar 

  • Krag, D.N., Meijer, S.J., Weaver, D.L., Loggie, B.W., Harlow, S.P., Tanabe, K.K., et al.,1995. Minimal access surgery for staging of malignant melanoma. Arch Surg 130, 654–658.

    PubMed  CAS  Google Scholar 

  • Krag, D.N., Harlow, S.P., Weaver, D.L., Ashikaga, T. 1998d. Technique of selected resection of radiolabeled lymph nodes in breast cancer patients. Semin Breast Dis 1, 111–116.

    Google Scholar 

  • Krag, D.N., Weaver, D., Ashikaga, T., et al., 1998c. The sentinel node in breast cancer. A multicenter validation study. New Engl J Med 339, 941–946.

    CAS  Google Scholar 

  • Krznaric, E., De Roo, M., Verbruggen, A., Stuyck, J., Mortelmans, L.1996. Chronic osteomyelitis: diagnosis with technetium-99m-d,l-hexamethylpropylene amine oxime labeled leukocytes. Eur J Nucl Med 23, 792–797.

    PubMed  CAS  Google Scholar 

  • Leak, L.V.,1970. Electron microscopic observations on lymphatic capillaries and the structural components of the connective tissue-lymph interface. Microvasc Res 2, 361–391.

    PubMed  CAS  Google Scholar 

  • Leong, S.P.L., Steinmetz, I., Habib, F., et al.,1997. Optimal selective sentinel lymph node dissection in primary malignant melanoma. Arch Surg 132, 666–673.

    PubMed  CAS  Google Scholar 

  • Leong, S.P.L., Donegan, E., Heffernan, W., et al.,2000. Adverse reactions to isosulfan blue during selective sentinel lymph node dissection in melanoma. Ann Surg Oncol 7, 361–366.

    PubMed  CAS  Google Scholar 

  • Lin, K.M., Patel, T.H., Ray, A., et al.,2004. Intradermal radioisotope is superior to peritumoral blue dye or radioisotope in identifying breast cancer sentinel nodes. J Am Coll Surg 199, 561–566.

    PubMed  Google Scholar 

  • Lin, Y.S., Tzeng, C.C., Huang, K.F., Kang, C.Y., Chia, C.C., Hsieh, J.F., 2005. Sentinel node detection with radiocolloid lymphatic mapping in early invasive cervical cancer. Int J Gynecol Cancer 15, 273–277.

    PubMed  CAS  Google Scholar 

  • Linehan, D.C., Hill, A.D.K., Tran, K.N., et al., 1999a. Sentinel lymph node localization in breast cancer: unfiltered isotope is superior to filtered. J Am Coll Surg 188, 377–381.

    CAS  Google Scholar 

  • Linehan, D.C., Hill, A.D.K., Akhurst, T., et al., 1999b. Intradermal radiocolloid and intraparenchymal blue dye injection optimize sentinel node identification in breast cancer patients. Ann Surg Oncol 6, 450–454.

    CAS  Google Scholar 

  • Lorberboym, M., Pastores, G.M., Kim, C.K., Hermann, G., Glajchen, N., Machac, J.,1997. J Nucl Med 38, 890–895.

    PubMed  CAS  Google Scholar 

  • Love, C., Marwin, S.E., Tomas, M.B., et al.,2004. Diagnosing infection in the failed joint replacement: a comparison of coincidence detection 18F-FDG and 111In-labeled leukocyte/99mTc-sulphur colloid marrow imaging. J Nucl Med 45, 1864–1871.

    PubMed  Google Scholar 

  • Luk, S.C., Nopajaroonsri, C., Simon, G.T.,1982. The architecture of the normal lymph node and hemolymph node. Amer J Anat 164, 275–309.

    Google Scholar 

  • McCarter, M.D., Yeung, H., Yeh, S., Fey, J., Borgen, P.I., Cody, H.S. III., 2001. Localization of the sentinel node in breast cancer: identical results with same-day and day-before isotope injection. Ann Surg Oncol 8, 682–686.

    PubMed  CAS  Google Scholar 

  • McMasters, K.M., Chao, C., Wong, S.L., et al.,2002. Interval sentinel lymph nodes in melanoma. Arch Surg 137, 543–549.

    PubMed  Google Scholar 

  • McMasters, K.M., Wong, S.L., Martin, R.C.G. II, et al.,2001. Dermal injection of radioactive colloid is superior to peritumoral injection for breast cancer sentinel lymph node biopsy: results of a multi-institutional study. Ann Surg 233, 676–687.

    PubMed  CAS  Google Scholar 

  • Medina-Franco, H., Beenken, S.W., Heslin, M.J., Urist, M.M.,2001. Sentinel node biopsy for cutaneous melanoma in the head and neck. Ann Surg Oncol 8, 716–719.

    PubMed  CAS  Google Scholar 

  • Moffat, F.L.,2005. Lymph node staging surgery and breast cancer: potholes in the fast lane from more to less. J Surg Oncol 89, 53–60.

    PubMed  Google Scholar 

  • Moffat, F.L., Ashikaga, T., Krag, D.N.,2000. Sentinel node biopsy for breast cancer: showtime or dress rehearsal? In Vivo 14, 255–264.

    Google Scholar 

  • Moffat, F.L., Gulec, S.A., Sittler, S.Y., et al.,1999. Unfiltered sulphur colloid and sentinel node biopsy for breast cancer: technical and kinetic considerations. Ann Surg Oncol 6, 746–755.

    PubMed  Google Scholar 

  • Moffat, F.L., Krag, D.N.,2003. Should surgeons abandon routine axillary dissection for sentinel node biopsy in early breast cancer? In: Nabholtz, J-M., Tonkin, K., Reese, D.M., Aapro, M.S., Buzdar, A.U. (Eds.). Breast Cancer Management. Application of Clinical and Translational Evidence to Patient Care (2nd Ed.). Lippincott Williams & Wilkins, Philadelphia, pp. 59–66.

    Google Scholar 

  • Montgomery, L.L., Thorne, A.C., Van Zee, K.J., et al.,2002. Isosulfan blue dye reactions during sentinel lymph node mapping for breast cancer. Anesth Analg 95, 385–388.

    PubMed  Google Scholar 

  • Morton, D.L., Cochran, A.J., Thompson, J.F., Elashoff, R., Essner, R., Glass, E.C., et al.,2005. Sentinel node biopsy for early-stage melanoma. Accuracy and morbidity in MSLT-I, an international multicenter trial. Ann Surg 242, 302–313.

    PubMed  Google Scholar 

  • Morton, D.L., Thompson, J.F., Essner, R., et al.,1999. Validation of the accuracy of intraoperative lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma. A multicenter trial. Ann Surg 230, 453–465.

    PubMed  CAS  Google Scholar 

  • Morton, D.L., Wen, D-R., Foshag, L.J., Essner, R., Cochran, A.1993. Intraoperative lymphatic mapping and selective cervical lymphadenectomy for early-stage melanomas of the head and neck. J Clin Oncol 11, 1751–1756.

    PubMed  CAS  Google Scholar 

  • Morton, D.L., Wen, D-R., Wong, J.H., et al.,1992. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 27, 392–399.

    Google Scholar 

  • Nopajaroonsri, C., Simon, G.T., 1971a. Phagocytosis of colloidal carbon in a lymph node. Amer J Pathol 65, 25–42.

    CAS  Google Scholar 

  • Nopajaroonsri, C., Luk, S.C., Simon, G.T., 1971b. Ultrastructure of the normal lymph node. Amer J Pathol 65, 1–24.

    CAS  Google Scholar 

  • Norman, J., Cruse, C.W., Espinosa, C., et al.,1991. Redefinition of cutaneous lymphatic drainage with the use of lymphoscintigraphy for malignant melanoma. Amer J Surg 162, 432–437.

    PubMed  CAS  Google Scholar 

  • Norman, J., Wells, K., Kearney, R., Cruse, C.W., Berman, C., Reintgen, D. 1993. Identification of lymphatic drainage basins in patients with cutaneous melanoma. Semin Surg Oncol 9, 224–227.

    PubMed  CAS  Google Scholar 

  • North, J.H. Jr., Spellman, J.E.,1996. Role of sentinel node biopsy in the management of malignant melanoma. Oncology 10, 1237–1242.

    PubMed  Google Scholar 

  • O’Brien, C.J., Uren, R.F., Thompson, J.F.,1995. Prediction of potential metastatic sites in cutaneous head and neck melanoma using lymphoscintigraphy. Amer J Surg 170, 461–466.

    PubMed  CAS  Google Scholar 

  • Ollila, D.W., Foshag, L.J., Essner, R., Stern, S.L., Morton, D.L.,1999. Parotid region lymphatic mapping and sentinel lymphadenectomy for cutaneous melanoma. Ann Surg Oncol 6, 150–154.

    PubMed  CAS  Google Scholar 

  • Palestro, C.J., Kim, C.K., Swyer, A.J., et al.,1990. Total hip arthroplasty: periprosthetic indium-111-labeled leukocyte activity and complementary technetium-99 m-sulphur colloid imaging in suspected infection. J Nucl Med 31, 1950–1955.

    PubMed  CAS  Google Scholar 

  • Palestro, C.J., Mehta, H.H., Patel, M., et al.,1998. Marrow versus infection in the Charcot joint: indium-111 leukocyte and technetium-99 m sulphur colloid scintigraphy. J Nucl Med 39, 346–350.

    PubMed  CAS  Google Scholar 

  • Palestro, C.J., Love, C., Tronco, G.G., Tomas, M.B., Rini, J.N.,2006. Combined labeled leukocyte and technetium 99m sulphur colloid bone marrow imaging for diagnosing musculoskeletal infection. RadioGraphics 26, 859–870.

    PubMed  Google Scholar 

  • Palestro, C.J., Roumanas, P., Swyer, A.J., Kim, C.K., Goldsmith, S.J.,1992. Diagnosis of musculoskeletal infection using combined In-111 labeled leukocyte and Tc-99 m marrow imaging. Clin Nucl Med 17, 269–273.

    PubMed  CAS  Google Scholar 

  • Palestro, C.J., Swyer, A.J., Kim, C.K., Goldsmith, S.J.,1991. Infected knee prosthesis: diagnosis with In-111 leukocyte, Tc-99m sulphur colloid and Tc-99 m MDP imaging. Radiology 179, 645–648.

    PubMed  CAS  Google Scholar 

  • Palestro, C.J., Torres, M.A.,1997. Radionuclide imaging in orthopedic infections. Semin Nucl Med 27, 334–345.

    PubMed  CAS  Google Scholar 

  • Patten, L.C., Berger, D.H., Rodriguez-Bigas, M., et al.,2004. A prospective evaluation of radiocolloid and immunohistochemical staining in colon carcinoma lymphatic mapping. Cancer 100, 2104–2109.

    PubMed  Google Scholar 

  • Payoux, P., Dekeister, C., Lopez, R., Lauwers, F., EsquerrĂ©, J.P., Paoli, J.R.,2005. Effectiveness of lymphoscintigraphic sentinel node detection for cervical staging of patients with squamous cell carcinoma of the head and neck. J Oral Maxillofac Surg 63, 1091–1095.

    PubMed  Google Scholar 

  • Pijpers, R., Collet, G.J., Meijer, S., Hoekstra, O.S.,1995. The impact of dynamic lymphoscintigraphy and gamma probe guidance on sentinel node biopsy in melanoma. Eur J Nucl Med 22, 1238–1241.

    PubMed  CAS  Google Scholar 

  • Ranieri, J.M., Wagner, J.D., Wenck, S.D., Calley, C., Coleman, J.J. III, 2004. The prognostic relevance of sentinel lymph node biopsy in thin melanoma patients. Ann Surg Oncol 11, S122.

    Google Scholar 

  • Raut, C.P., Daley, D., Hunt, K.K., et al.,2004. Anaphylactoid reactions to isosulfan blue dye during breast cancer lymphatic mapping in patients given preoperative prophylaxis. J Clin Oncol 22, 567–568.

    PubMed  Google Scholar 

  • Reintgen, D., Albertini, J., Miliotes, G., et al.,1995. The accurate staging and modern day treatment of malignant melanoma. Cancer Res Ther Control 4, 183–197.

    Google Scholar 

  • Reintgen, D.S., Cruse, C.W., Wells, K., et al.,1994. The orderly progression of melanoma nodal metastases. Ann Surg 220, 759–767.

    PubMed  CAS  Google Scholar 

  • Roeske, J.C., Lujan, A., Reba, R.C., Penney, B.C., Yamada, S.D., Mundt, A.J., 2005. Incor-poration of SPECT bone marrow imaging into intensity modulated whole-pelvic radiation therapy treatment planning for gynecologic malignancies. Radiother Oncol 77, 11–17.

    PubMed  Google Scholar 

  • Ross, G.L., Shoaib, T., Soutar, D.S., et al.,2002. The use of sentinel node biopsy to upstage the clinically N0 neck in head and neck cancer. Arch Otolaryngol Head Neck Surg 128, 1287–1290.

    PubMed  Google Scholar 

  • Ross, M.I., Reintgen, D., Balch, C.M.,1993. Selective lymphadenectomy: emerging role for lymphatic mapping and sentinel node biopsy in the management of early stage melanoma. Sem Surg Oncol 9, 219–223.

    CAS  Google Scholar 

  • Rousseau, D.L., Ross, M.I., Johnson, M.M., Prieto, V.G., Lee, J.E., Mansfield, P.F., Gershenwald, J.E.,2003. Revised American Joint Committee on Cancer Staging criteria accurately predict sentinel lymph node positivity in clinically node-negative melanoma patients. Ann Surg Oncol 10, 569–574.

    PubMed  Google Scholar 

  • Sage, H., Gozun, B.V.,1958. Lymphatic scintigrams: method for studying function of lymphatics and lymph nodes. Cancer 11, 200–203.

    PubMed  CAS  Google Scholar 

  • Saha, S., Dan, A.G., Berman, B., et al., 2004a. Lymphazurin 1% versus 99mTc sulphur colloid for lymphatic mapping in colorectal tumors: a comparative analysis. Ann Surg Oncol 11, 21–26.

    Google Scholar 

  • Saha, S., Dan, A.G., Beutler, T., et al. 2004b. Sentinel lymph node mapping technique in colon cancer. Semin Oncol 31, 374–381.

    Google Scholar 

  • Sainte-Marie, G., Peng, F.S.,1986. Diffusion of a lymph-carried antigen in the fiber network of the lymph node of the rat. Cell Tissue Res 245, 481–486.

    PubMed  CAS  Google Scholar 

  • Sainte-Marie, G., Peng, F.S., Belisle, C.,1982. Overall architecture and pattern of lymph flow in the rat lymph node. Amer J Anat 275–279.

    Google Scholar 

  • Schauwecker, D.S.,1992. The scintigraphic diagnosis of osteomyelitis. Amer J Roentgenol 158, 9–18.

    CAS  Google Scholar 

  • Seabold, J.E., Nepola, J.V.,1999. Imaging techniques for evaluation of postoperative orthopedic infections. Q J Nucl Med 43, 21–28.

    PubMed  CAS  Google Scholar 

  • Seabold, J.E., Nepola, J.V., Marsh, J.L., et al.,1991. Postoperative bone marrow alterations: potential pitfalls in the diagnosis of osteomyelitis with In-111-labeled leukocyte scintigraphy. Radiology 180, 741–747.

    PubMed  CAS  Google Scholar 

  • Shen, P., Glass, E.C., DiFronzo, L.A., Giuliano, A.E.,2001. Dermal versus intra-parenchymal lymphoscintigraphy of the breast. Ann Surg Oncol 8, 241–248.

    PubMed  CAS  Google Scholar 

  • Siddiqui, A.R., Oseas, R.S., Wellman, H.N., Doerr, D.R., Baehner, R.L., 1979. Evaluation of bone-marrow scanning with technetium-99m sulphur colloid in pediatric oncology. J Nucl Med 20, 379–386.

    PubMed  CAS  Google Scholar 

  • Siegel, R.S., Hakimian, D., Spies, W., et al.,1999. Technetium-99m sulphur colloid scanning and correlative magnetic resonance imaging in patients with hairy cell leukemia and hypocellular bone marrow biopsies after 2-chlorodeoxyadenosine. Leuk Lymphoma 35, 171–177.

    PubMed  CAS  Google Scholar 

  • Silva, N. Jr., Anselmi, C.E., Anselmi, O.E., et al.,2005. Use of the gamma probe in sentinel lymph node biopsy in patients with prostate cancer. Nucl Med Commun 26, 1081–1086.

    PubMed  Google Scholar 

  • Sim, F.H., Taylor, W.F., Pritchard, D.J., et al.,1986. Lymphadenectomy in the management of stage I malignant melanoma: a prospective randomized study. Mayo Clin Proc 61, 697–705.

    PubMed  CAS  Google Scholar 

  • Slingluff, C.L., Stidham, K.R., Ricci, W.M., Stanley, W.E., Seigler, H.F., 1994. Surgical management of regional nodes in patients with melanoma. Experience with 4682 patients. Ann Surg 219, 120–130.

    PubMed  Google Scholar 

  • Solorzano, C.C., Ross, M.I., Delpassand, E., Mirza, N., Akins, J.S., Kuerer, H.M., et al.,2001. Utility of breast sentinel lymph node biopsy using day-before-surgery injection of high-dose 99mTc-labeled sulphur colloid. Ann Surg Oncol 8, 821–827.

    PubMed  CAS  Google Scholar 

  • Spiegel, M., Vesti, B., Shore, A., Franzeck, U.K., Becker, F., Bollinger, A.,1992. Pressure of lymphatic capillaries in human skin. Amer J Physiol 262, 1208–1210.

    Google Scholar 

  • Statius Muller, M.G., Borgstein, P.J., Pijpers, R., van Leeuwen, P.A.M., van Diest, P.J., Gupta, A., Meijer, S.,2000. Reliability of the sentinel node procedure in melanoma patients: analysis of failures after long-term follow-up. Ann Surg Oncol 7, 461–468.

    PubMed  CAS  Google Scholar 

  • Stojadinovic, A., Allen, P.J., Protic, M., Potter, J.F., Shriver, C.D., Nelson, J.M., Peoples, G.E.,2005. Colon sentinel lymph node mapping: practical surgical applications. J Am Coll Surg 201, 297–313.

    PubMed  Google Scholar 

  • Strand, S.E., Persson, B.R.R.,1979. Quantitative lymphoscintigraphy: basic concepts for optimal uptake of radiocolloids in the parasternal lymph nodes of rabbits. J Nucl Med 20, 1038–1046.

    PubMed  CAS  Google Scholar 

  • Sumner, W.E. III, Ross, M.I., Mansfield, P.F., Lee, J.E., Prieto, V.G., Schacherer, C.W., Gershenwald, J.E.,2002. Implications of lymphatic drainage to unusual sentinel lymph node sites in patients with primary cutaneous melanoma. Cancer 95, 354–360.

    PubMed  Google Scholar 

  • Tafra, L., Lannin, D.R., Swanson, M.S., et al.,2001. Multicenter trial of sentinel node biopsy for breast cancer using both technetium sulphur colloid and isosulfan blue dye. Ann Surg 233, 51–59.

    PubMed  CAS  Google Scholar 

  • Tanis, P.J., van Rijk, M.C., Nieweg, O.E.,2005. The posterior lymphatic network of the breast rediscovered. J Surg Oncol 91, 195–198.

    PubMed  Google Scholar 

  • Tanner, M.L., Hoh, C.K., Bashey, A., et al.,2003. FLAG chemotherapy followed by allogeneic stem cell transplant using nonmyeloablative conditioning induces regression of myelolfibrosis with myeloid metaplasia. Bone Marrow Transplantation 32, 581–585.

    PubMed  CAS  Google Scholar 

  • Teal, C.B., Slocum, J.P., Akin, E.A.,2005. Evaluation of the benefit is using blue dye in addition to radioisotope for sentinel lymph node biopsy in patients with breast cancer. Breast J 11, 391–393.

    PubMed  Google Scholar 

  • Thelmo, M.C., Morita, E.T., Treseler, P.A., Nguyen, L.H., Allen, R.E. Jr., Sagebiel, R.W., Kashani-Sabet, M., Leong, S.P.L.,2001. Micrometastasis to in-transit lymph ndoes from extremity and truncal malignant melanoma. Ann Surg Oncol 8, 444–448.

    PubMed  CAS  Google Scholar 

  • Thompson, J.F., McCarthy, W.H., Bosch, C.M.J.,1995. Sentinel node status as an indicator of the presence of metastatic melanoma in regional lymph nodes. Melanoma Res 5, 255–260.

    PubMed  CAS  Google Scholar 

  • Tonakie, A., Sondak, V., Yahanda, A., Wahl, R.L.,2000. Reproducibility of lymphoscintigraphic drainage patterns in sequential 99mTc-human serum albumin and 99mTc-sulphur colloid studies: implications for sentinel node identification in melanoma. Surgery 127, 955–962.

    Google Scholar 

  • Uren, R.F., Howman-Giles, R., Thompson, J.F.,1994. Lymphoscintigraphy to identify sentinel lymph nodes in patients with melanoma. Melanoma Res 4, 395–399.

    PubMed  CAS  Google Scholar 

  • Uren, R.F., Howman-Giles, R.B., Shaw, H.M., Thompson, J.F., McCarthy, W.H., 1993. Lymphoscintigraphy in high-risk melanoma of the trunk: predicting draining node groups, defining lymphatic channels and locating the sentinel node. J Nucl Med 34, 1435–1440.

    PubMed  CAS  Google Scholar 

  • Vacquerano, J., Kraybill, W., Cheney, R., Kane, J.M.,2004. Indications for sentinel lymph node biopsy in thin melanomas. Ann Surg Oncol 11, S77–S78.

    Google Scholar 

  • Vera, D.R., Wallace, A.M., Hoh, C.K., Mattrey, R.F.,2001. A synthetic macromolecule for sentinel node detection: 99mTc-DTPA-Mannosyl-Dextran. J Nucl Med 42, 951–959.

    PubMed  CAS  Google Scholar 

  • Veronesi, U., Adamus, J., Bandiera, D.C., et al.,1977. Inefficacy of immediate node dissection in stage I melanoma of the limb. New Engl J Med 297, 627–630.

    PubMed  CAS  Google Scholar 

  • Veronesi, U., Adamus, J., Bandiera, D.C., et al.,1982. Delayed regional lymph node dissection in stage I melanoma of the skin of the lower extremities. Cancer 49, 2420–2430.

    PubMed  CAS  Google Scholar 

  • Veronesi, U., Paganelli, G., Viale, G., et al.,1999. Sentinel lymph node biopsy and axillary dissection in breast cancer: results in a large series. J Natl Cancer Inst 91, 368–373.

    PubMed  CAS  Google Scholar 

  • Veronesi, U., Paganelli, G., Galimberti, V., et al.,1997. Sentinel node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph nodes. Lancet 349, 1864–1867.

    PubMed  CAS  Google Scholar 

  • Wells, K.E., Cruse, C.W., Daniels, S., Berman, C., Norman, J., Reintgen, D.S.,1994. The use of lymphoscintigraphy in melanoma of the head and neck. Plast Reconstr Surg 93, 757–761.

    PubMed  CAS  Google Scholar 

  • Wells, K.E., Rapaport, D.P., Cruse, C.W., Payne, W., Albertini, J., Berman, C., Lyman, G.H., Reintgen, D.S.,1997. Sentinel lymph node biopsy in melanoma of the head and neck. Plast Reconstr Surg 100, 591–594.

    PubMed  CAS  Google Scholar 

  • White, D.C., Schuler, F.R., Pruitt, S.K., Culhane, D.K., Seigler, H.F., Coleman, R.E., Tyler, D.,1999. Timing of sentinel lymph node mapping after lymphoscintigraphy. Surgery 126, 156–161.

    PubMed  CAS  Google Scholar 

  • Wong, S.L., Edwards, M.J., Chao, C., et al.,2001. Sentinel lymph node biopsy for breast cancer: impact of the number of sentinel nodes removed on the false-negative rate. J Am Coll Surg 192, 684–691.

    PubMed  CAS  Google Scholar 

  • Woznick, A., Franco, M., Bendick, P., Benitez, P.R.,2006. Sentinel lymph node dissection for breast cancer: how many nodes are enough and which technique is optimal. Amer J Surg 191, 330–333.

    PubMed  Google Scholar 

  • Wrightson, W.R., Wong, S.L., Edwards, M.J., Chao, C., Reintgen, D.S., Ross, M.I., et al.,2003. Complications associated with sentinel lymph node biopsy for melanoma. Ann Surg Oncol 10, 676–680.

    PubMed  Google Scholar 

  • Zapas, J.L., Coley, H.C., Beam, S.L., Brown, S.D., Jablonski, K.A., Elias, E.G.,2003. The risk of regional lymph node metastases in patients with melanoma less than 1.0 mm thick: recommendations for sentinel lymph node biopsy. J Am Coll Surg 197, 403–407.

    PubMed  Google Scholar 

  • Zogakis, T.G., Wetherille, R.E., Christensen, R.D., et al.,2005. Intraoperative subareolar injection of 99mTc-labeled sulphur colloid results in consistent sentinel lymph node identification. Ann Surg Oncol 12, 167–172.

    PubMed  Google Scholar 

  • Zulfikaroglu, B., Koc, M., Kucuk, O., Ozalp, N., Aras, G.,2005. Intraoperative lymphatic mapping and sentinel lymph node biopsy using radioactive tracer in gastric cancer. Surgery 138, 899–904.

    PubMed  Google Scholar 

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Authors
  1. Frederick L. Moffat Jr.
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  2. Seza A. Gulec
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  1. Department of Radiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, 21205

    Jeff W.M. Bulte

  2. Institute of Psychiatry King’s College London, Center for the Cellular Basis of Behaviour, 125 Coldharbour Lane, London SE5 9NU, United Kingdom

    Michel M.J. Modo

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Moffat, F.L., Gulec, S.A. (2008). Sulphur Colloid for Imaging Lymph Nodes and Bone Marrow. In: Bulte, J.W., Modo, M.M. (eds) Nanoparticles in Biomedical Imaging. Fundamental Biomedical Technologies, vol 102. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72027-2_13

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