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VEGF Signal Tranduction in Angiogenesis

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Angiogenesis

The development of a number of novel tumor therapies targeting the function of vascular endothelial growth factors (VEGFs) and their receptors has promoted an interest in understanding signal transduction regulating angiogenesis, i.e. formation of new blood vessels. The VEGFRs regulate many if not all aspects of endothelial cell function during active angiogenesis, and mediate survival signals during endothelial cell quiescence. Most tumors produce VEGF as a consequence of the hypoxic tumor microenvironment, leading to persistent stimulation of angiogenesis necessary for an expansion of the tumor as well as tumor spread through the circulation. Increased understanding of VEGFR signal transduction properties may allow development of fine-tuned therapy, targeting pathways critical in formation of new tumor vessels while preserving pathways required for survival of endothelial cells in normal vessels.

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Authors and Affiliations

  1. Department of Genetics and Pathology, Uppsala University, 751 85, Uppsala, Sweden

    Harukiyo Kawamura, Xiujuan Li & Lena Claesson-Welsh

  2. Deptartment of Medical Cell Biology, Uppsala University, 751 85, Uppsala, Sweden

    Michael Welsh

Authors
  1. Harukiyo Kawamura
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  2. Xiujuan Li
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  3. Michael Welsh
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  4. Lena Claesson-Welsh
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Editor information

Editors and Affiliations

  1. Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

    William D. Figg

  2. Department of Surgery Harvard Medical School and Vascular Biology Program, Children's Hospital Boston, Boston, MA, USA

    Judah Folkman

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© 2008 Springer Science+Business Media, LLC

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Kawamura, H., Li, X., Welsh, M., Claesson-Welsh, L. (2008). VEGF Signal Tranduction in Angiogenesis. In: Figg, W.D., Folkman, J. (eds) Angiogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-71518-6_18

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  • DOI: https://doi.org/10.1007/978-0-387-71518-6_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-71517-9

  • Online ISBN: 978-0-387-71518-6

  • eBook Packages: MedicineMedicine (R0)

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