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Cavernous Malformations and Other Vascular Diseases

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Principles and Practice of Stereotactic Radiosurgery

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Abstract

Intracranial cavernous malformations are angiographically occult developmental malformations of the vascular bed. These abnormal vascular connections may enlarge over time. The lesions can occur on a familial basis. Patients may be asymptomatic, although they often present with headaches, seizures, or parenchymal hemorrhages. Substantial advances in the cellular and molecular biology of the vasculogenesis, angiogenesis, and cardiovascular physiology of these anomalies along with findings from detailed clinicopathologic and clinicoradiologic retrospective and prospective longitudinal studies have led to a better understanding of these vascular malformations as a whole.

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Author information

Authors and Affiliations

  1. University of Pittsburgh, Pittsburgh, PA, USA

    Ajay Niranjan MBBS, MS, MCh (Assistant Professor of Neurological Surgery)

  2. Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA

    David Mathieu MD, FRCS(C) (Visiting Assistant Professor), John C. Flickinger MD (Professor) & L. Dade Lunsford MD, FACS (Professor and Chairman)

  3. University of Pittsburgh, Pittsburgh, PA, USA

    Douglas Kondziolka MD, FRCS, FACS (Professor of Neurological Surgery)

Authors
  1. Ajay Niranjan MBBS, MS, MCh
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  2. David Mathieu MD, FRCS(C)
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  3. Douglas Kondziolka MD, FRCS, FACS
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  4. John C. Flickinger MD
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  5. L. Dade Lunsford MD, FACS
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA

    Lawrence S. Chin MD (Professor and Chairman) (Professor and Chairman)

  2. Department of Radiation Oncology, University of Maryland Medical School, Baltimore, MD, USA

    William F. Regine MD (Professor and Chairman) (Professor and Chairman)

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Niranjan, A., Mathieu, D., Kondziolka, D., Flickinger, J.C., Lunsford, L.D. (2008). Cavernous Malformations and Other Vascular Diseases. In: Chin, L.S., Regine, W.F. (eds) Principles and Practice of Stereotactic Radiosurgery. Springer, New York, NY. https://doi.org/10.1007/978-0-387-71070-9_49

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  • DOI: https://doi.org/10.1007/978-0-387-71070-9_49

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-71069-3

  • Online ISBN: 978-0-387-71070-9

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