Meningioma: Surgery Perspective

  • Lawrence S. Chin
  • Pulak Ray
  • John Caridi


The first successful documented resection of a meningioma—a benign, slow-growing tumor—was performed by Zanobi Pecchiolo (1801–1866) at Siena University. In a vast surgical series published in 1847, 1524 cases were described, one of which was a large meningioma removed from the right sinciput through a triangular flap. Then on December 15, 1887, William W. Keen (1837–1932) was the first neurosurgeon to successfully resect a meningioma in the United States. The patient proceeded to survive for 30 years without any clinical signs of recurrence [1]. Because of much debate over the etiology and pathogenesis of this tumor, it was not until 1922 that Harvey Cushing, in his text entitled Meningiomas, Their Classification, Regional Behavior, Life History, and Surgical End Results, characterized the tumor as a meningioma, thus leaving room for the histogenetic type to be clarified [2], [3]. It is now known that meningiomas arise from transformed arachnoid cap cells that form slow-growing tumors that are attached to the overlying dura [4]. Whereas most are well circumscribed, approximately 10% spread diffusely following and sometimes invading the contours of the underlying bone. These are termed meningioma en plaque and are much more difficult to resect. Histologically, the World Health Organization (WHO) has separated meningiomas into three grades based on microscopic appearance [5].


Optic Nerve Cavernous Sinus Gamma Knife Radiosurgery Tinea Capitis Preoperative Embolization 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Lawrence S. Chin
    • 1
  • Pulak Ray
    • 2
  • John Caridi
    • 3
  1. 1.Department of NeurosurgeryBoston University School of MedicineBostonUSA
  2. 2.Department of NeurosurgeryTemple UniversityPhiladelphiaUSA
  3. 3.Department of NeurosurgeryUniversity of MarylandBaltimoreUSA

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