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Remyelination of the Central Nervous System

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Interaction Between Neurons and Glia in Aging and Disease

Myelination in the central nervous system (CNS) is carried out by oligodendrocytes. These cells produce myelin, a lipid-rich biological membrane, which forms multilamellar, spirally wrapped sheets around axons. Myelination allows rapid saltatory conduction of action potentials, and contributes to the maintenance of axonal integrity. The devastating neurological effects caused by demyelinating CNS diseases illustrate the importance of the process.

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Authors and Affiliations

  1. Cambridge Centre for Brain Repair, and Neuroregeneration Laboratory, Department of Veterinary Medicine, University of Cambridge, Madingley Road, CB3 0ES, Cambridge, UK

    Charlotte C. Bruce & Robin J. M. Franklin

  2. Department of Biology, Swiss Federal Institute of Technology, Institute of Cell Biology, ETH Hönggerberg, CH-8093, Zürich, Switzerland

    João B. Relvas

Authors
  1. Charlotte C. Bruce
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  2. Robin J. M. Franklin
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  3. João B. Relvas
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Editor information

Editors and Affiliations

  1. University of Coimbra, 3004-504, Coimbra, Portugal

    João O. Malva , Ana Cristina Rego , Rodrigo A. Cunha  & Catarina R. Oliveira , ,  & 

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Bruce, C.C., Franklin, R.J.M., Relvas, J.B. (2007). Remyelination of the Central Nervous System. In: Malva, J.O., Rego, A.C., Cunha, R.A., Oliveira, C.R. (eds) Interaction Between Neurons and Glia in Aging and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-70830-0_19

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