TRAF Proteins in CD40 Signaling

  • Gail A. Bishop
  • Carissa R. Moore
  • Ping Xie
  • Laura L. Stunz
  • Zachary J. Kraus
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 597)

Abstract

The tumor necrosis factor receptor (TNFR) superfamily molecule CD40 is expressed by a wide variety of cell types following activation signals, and constitutively on B lymphocytes, macrophages, and dendritic cells. CD40 signals to cells stimulate kinase activation, gene expression, production of a antibody and a variety of cytokines, expression or upregulation of surface molecules, and protection or promotion of apoptosis. Initial steps in CD40-mediated signal cascades involve the interactions of CD40 with various members of the TNFR-associated factor (TRAF) family of cytoplasmic proteins. This review summarizes current understanding of the nature of these interactions, and how they induce and regulate CD40 functions.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Gail A. Bishop
    • 1
    • 2
  • Carissa R. Moore
  • Ping Xie
  • Laura L. Stunz
  • Zachary J. Kraus
  1. 1.Departments of Microbiology and Internal Medicine, Interdisciplinary Graduate Program in ImmunologyUniversity of IowaIowa CityUSA
  2. 2.Iowa City VAMCIowa CityUSA

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