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Pharmacotherapy of Diabetes: New Developments pp 53–65Cite as

Insulin and New Insulin Analogues with Focus on Type 2 Diabetes

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The underlying insulin resistance and impaired insulin secretion in patients with type 2 diabetes worsen over time, necessitating the use of antidiabetic drugs, often in combination, to control glycaemic levels [1]. From the UKPD study the main explanation for the progressive history of type 2 diabetes seems to be a failure of beta-cell function over time [2], while insulin resistance may be more constant from diagnosis [2]. Therefore, it is not surprising that insulin treatment is necessary in most patients 10–15 years after diagnosis to maintain of HbA1c level as close to normal as is safely possible [2]. A consensus recommendation for the treatment of type 2 diabetes has recently been published [1].

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Authors and Affiliations

  1. Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark

    Sten Madsbad

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  1. Aarhus University Hospital, Nørrebrogade 44, DK-8000, Aarhus, Denmark

    Carl Erik Mogensen MD

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Madsbad, S. (2007). Insulin and New Insulin Analogues with Focus on Type 2 Diabetes. In: Mogensen, C.E. (eds) Pharmacotherapy of Diabetes: New Developments. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69737-6_7

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  • DOI: https://doi.org/10.1007/978-0-387-69737-6_7

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