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Update on the Role of EGFR Inhibitors in Cancer Therapeutics

  • Chapter
Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy

Part of the book series: Cancer Treatment and Research ((CTAR,volume 135))

The epidermal growth factor receptor (EGFR) is a type I tyrosine kinase receptor that plays a central role in signal transduction pathways that regulate key cellular functions in epithelial malignancies.After ligand binding, EGFR homo- or heterodimerizes with other members of the EGFR family of receptors, such as HER-2, and activates a signaling cascade that participates in tumor proliferation, angiogenesis, survival, and invasion/metastasis (61). Multiple studies have demonstrated that EGFR is commonly overexpressed in a variety of epithelial malignancies (Table 1) and its high expression usually correlates with worse patient outcome (4, 34).

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  1. Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh, Pennsylvania, Pittsburgh, USA

    Michalis V. Karamouzis MD, PhD & Athanassios Argiris MD

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  1. University of California San Francisco and UCSF Comprehensive Cancer Center at Mount Zion, 1600 Divisadero Street, 94143, San Francisco, CA, USA

    Stanley P. L. Leong MD, FACS

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Karamouzis, M.V., Argiris, A. (2007). Update on the Role of EGFR Inhibitors in Cancer Therapeutics. In: Leong, S.P.L. (eds) Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy. Cancer Treatment and Research, vol 135. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69219-7_19

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