Landmarks and Advances in Translational Lymphology

  • Marlys H. Witte
  • Kimberly Jones
  • Michael Bernas
  • Charles L. Witte
Part of the Cancer Treatment and Research book series (CTAR, volume 135)

The lymph vascular system parallels the blood vasculature and as one of its key functions, returns liquid and solute to the bloodstream, including macromolecules that have escaped from blood capillaries and entered the interstitium. In conjunction with interspersed lymph nodes and lymphoid organs, the lymphatic vasculature also acts as a conduit for trafficking immune cell populations. Lymphatics are involved in diverse developmental, growth, repair, and pathologic processes similar to but distinct from those affecting the blood vasculature. Interference with the blood–lymph circulatory loop produces edema, scarring, nutritional, and immunodysregulatory disorders as well as disturbances in lymph(hem)angiogenesis (lymphedema–angiodysplasia syndromes). The lymphatic system – encompassing lymphatics, lymph, lymph nodes, and lymphocytes – is also the stage on which key events in tumor biology and cancer progression are played out, and historically, also has formed the basis for evaluation, prognostication, and both operative and nonoperative treatment of most cancers. Interpreted in the light of landmark discoveries about the structure and function of the lymphatic system during the last century, recent advances in molecular lymphology combined with fresh insights and refined tools in clinical lymphology, including noninvasive lymphatic imaging, are fueling translation to the clinical arena, i.e., translational lymphology.


Lymphatic Vessel Lymphatic System Thoracic Duct Lymphatic Endothelial Cell Lymph Circulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Marlys H. Witte
    • 1
  • Kimberly Jones
    • 2
  • Michael Bernas
    • 1
  • Charles L. Witte
    • 1
  1. 1.Department of SurgeryUniversity of Arizona College of MedicineTucsonUSA
  2. 2.Department of Medicine (Oncology)University of UtahSalt LakeUSA

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