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Androgen-Regulated Genes in the Prostate

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Androgen Action in Prostate Cancer

Abstract

The androgen receptor (AR) and attendant signaling program regulates key components of prostate organogenesis, contributes to normal physiological functions, and influences organ-specific pathologies that include benign prostate hypertrophy and carcinoma. AR signaling regulates genetic programs in both epithelium and in cells comprising the stromal compartment of the prostate. Given that multiple cellular and tissue effects are attributable to AR signaling, increased knowledge of the AR-regulated gene expression network is central to an understanding of prostate function in health and disease. Androgen-responsive gene expression can be regulated at the level of transcription, RNA processing, RNA stability, protein translation, or protein stability. The products of these genes form part of a network of biochemical interactions leading to physiological consequences for prostate development and pathology. This review focuses on recent advances in the identification of genes regulated by androgens and the AR and provides context for their potential influence on normal prostate physiology and mechanisms of disease.

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  1. Fred Hutchinson Cancer Research Center, Division of Human Biology, 1100 Fairview Ave N, MS, D4-100, Seattle, WA 91809-1024, USA

    Peter S. Nelson

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  1. Nigel Clegg
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Clegg, N., Nelson, P.S. (2009). Androgen-Regulated Genes in the Prostate. In: Mohler, J., Tindall, D. (eds) Androgen Action in Prostate Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69179-4_27

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