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Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics pp 111–136Cite as

Solubility Issues in Early Discovery and HTS

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Part of the book series: Biotechnology: Pharmaceutical Aspects ((PHARMASP,volume VI))

Abstract

Drug discovery programs begin with target identification and validation for diseases with unmet medical needs (Figure 1). Drug discovery targets that are currently available mostly fall into two categories, with 45% being receptors and 28% being enzymes (Table 1) (Drews, 2000). There are only 483 targets addressed by all drugs in the pharmaceutical industry, which is a relatively small number compared to the estimated 3000–10,000 disease relevant genes (Meisner et al., 2004). It is evident that the drug target universe is far from being fully exploited.

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Authors and Affiliations

  1. Wyeth Research, Princeton, NJ

    LI DI & EDWARD H. KERNS

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  1. LI DI
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  2. EDWARD H. KERNS
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Editors and Affiliations

  1. Catholic University of Leuven, Belgium

    Patrick Augustijns

  2. Janssen Pharmaceutica N.V., Beerse, Belgium

    Marcus E. Brewster

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DI, L., KERNS, E.H. (2007). Solubility Issues in Early Discovery and HTS. In: Augustijns, P., Brewster, M.E. (eds) Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics. Biotechnology: Pharmaceutical Aspects, vol VI. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69154-1_4

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