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Neuroimmunology of Sleep pp 167–174Cite as

Selective REM Sleep Deprivation and Its Impact on the Immune Response

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Abstract

Shortly after the seminal paper of Aserinsky and Kleitman (1953) in which they reported the existence of the rapid eye movements sleep stage, the French school lead by Jouvet called this sleep stage as Sommeil Paradoxale, i.e., paradoxical sleep, mainly because some of its features were difficult to explain at that time (Jouvet and Michel 1960a, 1960b). After almost 50 years of intensive experimental analysis concerning this stage, the full understanding of the biological role of REM sleep remains elusive.

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References

  • Aserinsky, E., and Kleitman, N. (1953) Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. Science 118(3062), 273–274.

    Article  PubMed  CAS  Google Scholar 

  • Benca, R.M., Kushida, C.A., Everson, C.A., Kalski, R., Bergmann, B.M., Rechtschaffen A. Bergmann, B.M., Kushida, C.A., Everson, C.A., Gilliland, M.A., Obermeyer, W., and Rechtschaffen, A. (1989) Sleep deprivation in the rat: II. Methodology. Sleep 12, 5–12.

    Google Scholar 

  • Coenen, A.M.L., and Van Luijtelaar, E.L.J.M. (1985) Stress induced by three procedures of deprivation of paradoxical sleep. Physiol Behav 35, 501–504.

    Article  PubMed  CAS  Google Scholar 

  • Coenen, A.M., and Van Hulzen, Z.J. (1980) Paradoxical sleep deprivation in animal studies: Some methodological considerations. Prog Brain Res 53, 325–330.

    PubMed  CAS  Google Scholar 

  • Elomaa, E. (1979) The cuff pedestal: An alternative to flowerpots? Physiol Behav 23(4), 669–672.

    Article  PubMed  CAS  Google Scholar 

  • Dinges, D., Douglas, S., Zaugg, L., Campbell, D., McMann, J., Whitehouse, W., Orne, E., Kapoor, S., Icaza, E., and Orne, M. (1994) Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation. J Clin Invest 93 1930–1939.

    Article  PubMed  CAS  Google Scholar 

  • Dinges, D.F., Douglas, S.D., Hamarman, S., Zaugg, L., Kapoor, S. (1995) Sleep deprivation and human immune function. Adv Neuroimmunol. 5(2): 97–110.

    Article  PubMed  CAS  Google Scholar 

  • Endo, T., Roth, C., Landolt, H.P., Werth, E., Aeschbach, D., Achermann, P., and Borbély, A.A. (1998) Selective REM sleep deprivation in humans: Effects on sleep and sleep EEG. Am J Physiol Regul Integr Comp Physiol 274, 1186–1194.

    Google Scholar 

  • Horne, J.A., McGrath, M.J. (1984) The consolidation hypothesis for REM sleep function: stress and other confounding factors—a review. Biol Psychol 18(3): 165–184.

    Article  PubMed  CAS  Google Scholar 

  • Irwin, M., Mascovich, A., Gillin, J.C., Willoughby, R., Pike, J., and Smith, T. (1994) Partial sleep deprivation reduces natural killer cell activity in humans. Psychosom Med 56, 493–498.

    PubMed  CAS  Google Scholar 

  • Irwin, M. (2002) Effects of sleep and sleep loss on immunity and cytokines. Brain Behav Immun 16(5), 503–512.

    Article  PubMed  CAS  Google Scholar 

  • Jouvet, M., and Michel, F. (1960a) New research on the structures responsible for the “paradoxical phase” of sleep. J Physiol (Paris) 52, 130–131.

    CAS  Google Scholar 

  • Jouvet, M., and Michel, F. (1960b) Release of the “paradoxal phase” of sleep by stimulation of the brain stem in the intact and chronic mesencephalic cat. CR Seances Soc Biol Fil 154, 636–641.

    CAS  Google Scholar 

  • Jouvet, D., Vimont, R., Delorme, F., and Jouvet, M. (1964) Etude de la privation selective de la phase paradoxale de sommeil chez le chat. CR Soc Biol 158, 756–759.

    CAS  Google Scholar 

  • Jouvet-Mounier, D., Vimont, P., and Delorme, F. (1965) Study of the effects of sleep deprivation in the adult cat. J Physiol (Paris) 57(5), 636–637.

    CAS  Google Scholar 

  • Kovalzon, V.M., and Tsibulsky, V.L. (1984) REM sleep deprivation, stress and emotional behavior in rats. Behav Brain Res 14, 235–245.

    Article  PubMed  CAS  Google Scholar 

  • Mark, J., Heiner, L., and Godin, Y. (1970) Stress during experimental deprivation of paradoxical sleep. J Physiol (Paris) 62(Suppl 1), 185.

    Google Scholar 

  • Mendelson, W., Guthrie, R.D., Guynn, R., Harris, R.L., and Wyatt, R.J. (1974) Rapid eye movement (REM) sleep deprivation, stress and intermediary metabolism. J Neurochem 22(6), 1157–1159.

    Article  PubMed  CAS  Google Scholar 

  • Moldofsky, H. (1994) Central nervous system and peripheral immune functions and the sleep-wake system. J Psychiatry Neurosci. 19(5): 368–374.

    PubMed  CAS  Google Scholar 

  • Moldofsky, H., Lue, F., Davidson, J., and Gorczynski, R. (1989a) Effects of sleep deprivation in human immune functions. FASEB J 3, 1972–1977.

    CAS  Google Scholar 

  • Moldofsky, H., Lue, F., Davidson, J., Jephthah-Ochoa, J., Carayanniotis, K., and Gorczynski, R. (1989b) The effect of 64 hours of wakefulness on immune functions and plasma cortisol in humans. In: J. Horne (Ed.). Sleep′88. Gustav Fisher Verlag, Stuttgart, pp. 185–187.

    Google Scholar 

  • Ozturk, L., Pelin, Z., Karadeniz, D., Kaynak, H., Cakar, L., and Gozukirmizi, E. (1999) Effects of 48 hours sleep deprivation on human immune profile. Sleep Res Online 2(4), 107–111.

    PubMed  CAS  Google Scholar 

  • Palmblad, J., Cantell, K., Strander, H., Froberg, J., Karlsson, C.-G., Levi, L., Granstrom, M., Unger, P. (1976) Stressor exposure and immunologic response in man: interferon producing capacity and phagocytosis. Psychosom Res 20: 193–199.

    Article  CAS  Google Scholar 

  • Palmblad, J., Petrini, B., Wasserman, J., Akerstedt, T. (1979) Lymphocyte and Granulocyte reactions during sleep deprivation. Psychosomatic Medicine 41(4): 273–278.

    PubMed  CAS  Google Scholar 

  • Redwine, L. Dang, J., Hall, M., Irwin, M. (2003) Disordered sleep, nocturnal cytokines, and immunity in alcoholics. Psychosom Med 65(1), 75–85.

    Article  PubMed  CAS  Google Scholar 

  • Tobler, I., Murison, R., Ursin, R., Ursin, H., and Borbely, A.A. (1983) The effect of sleep deprivation and recovery sleep on plasma corticosterone in the rat. Neurosci Lett 35(3): 297–300.

    Article  PubMed  CAS  Google Scholar 

  • Suchecki, D., and Tufik, S. (2000) Social stability attenuates the stress in the modified multiple platform method for paradoxical sleep deprivation in the rat. Physiol Behav 68(3), 309–316.

    Article  PubMed  CAS  Google Scholar 

  • Suchecki, D., Duarte Palma, B., and Tufik, S. (2000) Sleep rebound in animals deprived of paradoxical sleep by the modified multiple platform method. Brain Res 875(1/2), 14–22.

    Article  PubMed  CAS  Google Scholar 

  • Van Hulzen, Z.J., and Coenen, A.M. (1980) The pendulum technique for paradoxical sleep deprivation in rats. Physiol Behav 25(6), 807–811.

    Article  PubMed  Google Scholar 

  • Van Luijtelaar, E.L., and Coenen, A.M. (1982) Differential behavioural effects of two instrumental paradoxical sleep deprivation techniques in rats. Biol Psychol 15(1/2), 85–93.

    Article  PubMed  Google Scholar 

  • Van Luijtelaar, E.L., and Coenen, A.M. (1986) Electrophysiological evaluation of three paradoxical sleep deprivation techniques in rats. Physiol Behav 36(4), 603–609.

    Article  PubMed  Google Scholar 

  • Velazquez-Moctezuma, J., Dominguez-Salazar, E., Cortes-Barberena, E., Najera-Medina, O., Retana-Marquez, S., Rodriguez-Aguilera, E., Jimenez-Anguiano, A., Cortes-Martinez, L., Ortiz-Muniz, R. (2004) Differential effects of rapid eye movement sleep deprivation and immobilization stress on blood lymphocyte subsets in rats. Neuroimmunomodulation. 11(4): 261–267.

    Article  PubMed  CAS  Google Scholar 

  • Vogel, G.W. (1975) A review of REM sleep deprivation. Arch Gen Psychiat 32, 749–761.

    PubMed  CAS  Google Scholar 

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Authors
  1. Javier Velazquez Moctezuma
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  2. José Ángel Rojas Zamorano
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  3. Enrique Esqueda León
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  4. Andrés Quintanar Stephano
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  5. Anabel Jiménez Anguiano
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Editor information

Editors and Affiliations

  1. Mount Sinai School of Medicine, New York, NY, USA

    S. R. Pandi-Perumal

  2. University of Buenow Aires, Buenos Aires, Argentina

    Daniel P. Cardinali

  3. Athens University Medical School, Athens, Greece

    George P. Chrousos

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© 2007 Springer

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Moctezuma, J.V., Zamorano, J.Á., León, E.E., Stephano, A.Q., Anguiano, A.J. (2007). Selective REM Sleep Deprivation and Its Impact on the Immune Response. In: Pandi-Perumal, S., Cardinali, D.P., Chrousos, G.P. (eds) Neuroimmunology of Sleep. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69146-6_9

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