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Cdk1, Plks, Auroras, and Neks: The Mitotic Bodyguards

  • Chapter
Hormonal Carcinogenesis V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 617))

“Omnis cellula e cellula,” in 1858, an important dogma in cell biology was born, when Rudolf Virchow established that every cell must derive from a preexisting cell. And indeed cell division is the only way for life to expend, it is also the way for immortalization, and unfortunately when uncontrolled also the way for cancer. But unrevealing mechanisms leading to cell division took quite a while. How does a mother cell divide to give two daughters? This is known as the cell cycle, which describes a series of events that insures faithfully transition of the genetic information from one cell generation to the next. These dividing mechanisms have been conserved throughout evolution; they underlie growth and development in all living organisms and are central to their heredity and evolution.

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Authors and Affiliations

  1. Universite Rennes Fac. de Medecine, Rennes, France

    Prigent Claude

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  1. Patrick Salaun
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  2. Yoann Rannou
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  3. Prigent Claude
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Editors and Affiliations

  1. Medical Center Department of Pharmacology, University of Kansas, Kansas City, KS, USA

    Jonathan J. Li PhD  & Sara A. Li PhD  & 

  2. Division of Cancer Biology, National Cancer Institute, Rockville, MD, USA

    Suresh Mohla PhD

  3. Hormone and Cancer Unit, U540, Montpellier University and INSERM, Montpellier, France

    Henri Rochefort MD/PhD

  4. Department of Cell Biology, Montpellier University 1-INSERM, U540 Hospital Arnaud de Villeneuve, Montpellier, France

    Thierry Maudelonde MD/PhD

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© 2008 Springer

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Salaun, P., Rannou, Y., Claude, P. (2008). Cdk1, Plks, Auroras, and Neks: The Mitotic Bodyguards. In: Li, J.J., Li, S.A., Mohla, S., Rochefort, H., Maudelonde, T. (eds) Hormonal Carcinogenesis V. Advances in Experimental Medicine and Biology, vol 617. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69080-3_4

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