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Hormonal Carcinogenesis V pp 129–138Cite as

Dynamics of Estrogen Receptor-mediated Transcriptional Activation of Responsive Genes In Vivo: Apprehending Transcription in Four Dimensions

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 617))

Estrogens, such as 17β-estradiol (E2), are commonly recognized as pivotal hormones controlling female reproductive physiology (1), but they also exhibit pleiotropic actions in male reproductive development and physiology, bone and lipid metabolisms, and the maintenance of the cardiovascular and neuronal systems (2–4). These effects of E2 are mainly transduced through specific receptors, the estrogen receptors (ERα and ERβ), although another protein, G protein-coupled receptor (GPR30) has been recently suggested to transduce some of the estrogenic responses (5). Further studies are awaited to identify the exact respective contribution of both pathways to E2 signaling. ERs are dimeric, intranuclear, ligand-dependent transcription factors belonging to the superfamily of nuclear receptors (NRs) (6). ERs classically recognize defined palindromic target DNA sequences located within the promoter regions of estrogen responsive target genes (7, 8). Upon binding its ligand, ER undergoes drastic conformational changes (8) that generate surfaces that associate with transcriptional cofactors that in turn allow the recruitment to the target promoter and activation of the RNA polymerase II complex (Pol II) (9).

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  1. Campus de Beaulieu Batiment 13, Rennes, France

    Raphaël Métivier

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Editors and Affiliations

  1. Medical Center Department of Pharmacology, University of Kansas, Kansas City, KS, USA

    Jonathan J. Li PhD  & Sara A. Li PhD  & 

  2. Division of Cancer Biology, National Cancer Institute, Rockville, MD, USA

    Suresh Mohla PhD

  3. Hormone and Cancer Unit, U540, Montpellier University and INSERM, Montpellier, France

    Henri Rochefort MD/PhD

  4. Department of Cell Biology, Montpellier University 1-INSERM, U540 Hospital Arnaud de Villeneuve, Montpellier, France

    Thierry Maudelonde MD/PhD

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Métivier, R. et al. (2008). Dynamics of Estrogen Receptor-mediated Transcriptional Activation of Responsive Genes In Vivo: Apprehending Transcription in Four Dimensions. In: Li, J.J., Li, S.A., Mohla, S., Rochefort, H., Maudelonde, T. (eds) Hormonal Carcinogenesis V. Advances in Experimental Medicine and Biology, vol 617. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69080-3_12

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