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MicroRNA in Human Cancer: One Step Forward in Diagnosis and Treatment

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Ovarian Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 622))

Cancer is a disease involving multistep dynamic changes in the genome. However, studies to date on the cancer genome have focused most heavily on protein-coding genes, and our knowledge on alterations of the functional noncoding sequences in cancer is largely absent. MicroRNAs (miRNAs) are ~22 nucleotide (nt) noncoding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or mRNA degradation. Mounting evidence shows that miRNAs may play an important role in tumor development, and a better understanding of their alteration in cancer genome and oncogenic property should contribute to the diagnosis and treatment of cancer.

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Zhang, L., Yang, N., Coukos, G. (2008). MicroRNA in Human Cancer: One Step Forward in Diagnosis and Treatment. In: Coukos, G., Berchuck, A., Ozols, R. (eds) Ovarian Cancer. Advances in Experimental Medicine and Biology, vol 622. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68969-2_6

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