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Abl Family Kinases in Development and Disease pp 26–47Cite as

Abl and Cell Death

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Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

The Abl tyrosine kinase contains nuclear-import and -export signals and undergoes nucleo-cytoplasmic shuttling in proliferating cells. The nuclear Abl is activated by DNA damage or tumor necrosis factor to promote cell death through transcription-dependent and -independent mechanisms. The oncogenic BCR-ABL tyrosine kinase is defective in nuclear import and functions as an inhibitor of apoptosis in the cytoplasm. If allowed to function in the nucleus, BCR-ABL also induces cell death. Abl interacts with several different types of death effectors. However, the precise mechanism by which Abl tyrosine kinase regulates cell death remains to be determined.

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  1. Division of Hematology-Oncology, Department of Medicine, Moores Cancer Center, School of Medicine, University of California San Diego, La Jolla, California, 92093, USA

    Jean Y. J. Wang

  2. Division of Biological Sciences, University of California-San Diego, La Jolla, California, USA

    Yosuke Minami & Jiangyu Zhu

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Wang, J.Y.J., Minami, Y., Zhu, J. (2006). Abl and Cell Death. In: Abl Family Kinases in Development and Disease. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68744-5_4

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