Abstract
C. Anfinsen could show that denatured (boiled or urea-treated) RNase could resume its correct folding once the temperature or urea concentration had been lowered [4]. He postulated that all proteins contain in their primary structure (amino acid sequence) the complete information which determines their secondary and tertiary structure (folding in 3-dimensional space). This hypothesis has proven fruitful (Nobel Price 1972).
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Buxbaum, E. (2007). Aiding in folding: molecular chaperones and chaperonins. In: Fundamentals of Protein Structure and Function. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-68480-2_14
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DOI: https://doi.org/10.1007/978-0-387-68480-2_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-26352-6
Online ISBN: 978-0-387-68480-2
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