Skip to main content

Venous Thrombosis and Pulmonary Embolism

  • Chapter
Minimally Invasive Bariatric Surgery

Abstract

Morbid obesity is a major risk factor for the development of deep venous thrombosis (DVT) and pulmonary embolism (PE). Thromboembolic complications are the most common cause of death in bariatric surgery and contribute significantly to postoperative morbidity (1). A study of risk factors for venous thromboembolism in hospitalized patients demonstrated an association with age over 40 years, obesity, and major surgery (2). The increased risk in the morbidly obese is attributable to a sedentary lifestyle, increased abdominal pressure, and the excessive weight resting on the inferior vena cava drainage. Additional risk factors include prior history of DVT or PE, immobility, pregnancy, oral contraceptive use, smoking, hypercoagulable states, malignancy, and trauma (Table 26-1). Although they are usually diagnosed as postoperative complications, DVT and PE may also occur in nonhospitalized patients. Studies of risk factors for thromboembolism in the general population have demonstrated an association with obesity, suggesting that morbid obesity is an independent risk factor for DVT and PE (3,4).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 249.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Eriksson S, Backman L, Ljungstrom KG. The incidence of clinical postoperative thrombosis after gastric surgery for obesity during 16 years. Obes Surg 1997;7:332–335.

    Article  CAS  PubMed  Google Scholar 

  2. Anderson FA, Wheeler B, Goldberg RJ, Hosmer DW, Forcier A. The prevalence of risk factors for venous thromboembolism among hospital patients. Arch Intern Med 1992; 152:1660–1664.

    Article  PubMed  Google Scholar 

  3. Goldhaber SZ, Savage DD, Garrison RJ, et al. Risk factors for pulmonary embolism. The Framingham study. Am J Med 1983;74:1023–1028.

    Article  CAS  PubMed  Google Scholar 

  4. Hansson PO, Eriksson H, Welin L, Svardsudd K, Wilhemsen L. Smoking and abdominal obesity. Risk factors for venous thromboembolism among middle-aged men. Arch Intern Med 1999;159:1886–1890.

    Article  CAS  PubMed  Google Scholar 

  5. Bosello O, Zamboni M. Visceral obesity and metabolic syndrome. Obes Rev 2000;1:47–56.

    Article  CAS  PubMed  Google Scholar 

  6. Batist G, Bothe A, Bern M, Bistrian BR, Blackburn GL. Low antithrombin III in morbid obesity: return to normal with weight reduction. JPEN 1983;7:447–449.

    Article  CAS  Google Scholar 

  7. Folsom AR, Qamhieh HT, Wing RR, et al. Impact of weight loss on plasminogen activator inhibitor (PAI-1), factor VII, and other hemostatic factors in moderately overweight adults. Arterioscler Thromb 1993;13:162–169.

    Article  CAS  PubMed  Google Scholar 

  8. Primrose JN, Davies JA, Prentice CRM, Hughes R, Johnston D. Reduction in factor VII, fibrinogen and plasminogen activator inhibitor-1 activity after surgical treatment of morbid obesity. Thromb Haemost 1992;68:396–399.

    CAS  PubMed  Google Scholar 

  9. Wu EC, Barba Ca. Current practices in the prophylaxis of venous thromboembolism in bariatric surgery. Obes Surg 2000;10:7–13.

    Article  CAS  PubMed  Google Scholar 

  10. Schwenk W, Bohm B, Fugener A, Muller JM. Intermittent pneumatic sequential compression (ISC) of the lower extremities prevents venous stasis during laparoscopic cholecystectomy. A prospective randomized study. Surg Endosc 1998;12:7–11.

    Article  CAS  PubMed  Google Scholar 

  11. Caprini JA, Arcelus JI, Laubach M, Size G, Hoffman KN, Coats RW, Blattner S. Postoperative hypercoagulability and deep vein thrombosis after laparoscopic cholecystectomy. Surg Endosc 1995;9:304–309.

    CAS  PubMed  Google Scholar 

  12. Nguyen NT, Luketich JD, Shurin MR, et al. Coagulation modifications after laparoscopic and open cholecystectomy in a swine model. Surg Endosc 1998;12:973–978.

    Article  CAS  PubMed  Google Scholar 

  13. Lindberg F, Rasmussen I, Siegbahn A, Bergqvist Dl. Coagulation activation after laparoscopic cholecystectomy in spite of thromboembolism prophylaxis. Surg Endosc 2000; 14:858–861.

    Article  CAS  PubMed  Google Scholar 

  14. Nguyen NT, Goldman CD, Ho HS, Gosselin RC, Singh A, Wolfe BM. Systemic stress response after laparoscopic and open gastric bypass. J Am Coll Surg 2002;194:557–566.

    Article  PubMed  Google Scholar 

  15. Clagett G, Reisch J. Prevention of venous thromboembolism in general surgical patients. Results of metaanalysis. Ann Surg 1988;208:227–240.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. Hirsh J, Warkentin TE, Shaughnessy SG, et al. Heparin and low-molecular weight heparin. Chest 2001;119:64S–94S.

    Article  CAS  PubMed  Google Scholar 

  17. Geerts WH, Heit JA, Clagett GP, et al. Prevention of venous thromboembolism. Chest 2001;119:132S–175S.

    Article  CAS  PubMed  Google Scholar 

  18. Sugerman HJ, Sugerman EL, Wolfe L, Kellum JM, Schweitzer MA, DeMaria EJ. Risks and benefits of gastric bypass in morbidly obese patients with severe venous stasis disease. Ann Surg. 2001;234:41–46.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  19. National Institutes of Health. Consensus conference on prevention of venous thrombosis and pulmonary embolism. JAMA 1986;256:744–748.

    Article  Google Scholar 

  20. Prevention of fatal postoperative pulmonary embolism by low doses of heparin: an international multicentre study. Lancet 1975;2:45–51.

    Google Scholar 

  21. Kakkar VV, Cohen AT, Edmonson RA, et al. Low molecular weight heparin versus standard heparin for prevention of venous thromboembolism after major abdominal surgery. Lancet 1993;341:256–259.

    Article  Google Scholar 

  22. Palmer AJ, Schramm W, Kirchof B. Low molecular weight heparin and unfractionated heparin for prevention of thromboembolism in general surgery: a meta-analysis of randomized clinical trials. Haemostasis 1997;27:65–74.

    CAS  PubMed  Google Scholar 

  23. Cleymol G. Effects of obesity on pharmacokinetics: implications for drug therapy. Clin Pharmacol 2000;39:215–231.

    Article  Google Scholar 

  24. Levine MN, Planes A, Hirsh J, Goodyear M, Vochelle N, Gent M. The relationship between anti-factor Xa level and clinical outcome in patients receiving enoxaparin low molecular weight heparin to prevent deep vein thrombosis after hip replacement. Thromb Haemost 1989;62:940–944.

    CAS  PubMed  Google Scholar 

  25. Kovacs MJ, Weir K, MacKinnon K, Keeney M, Brien WF, Cruickhank MK. Body weight does not predict for anti-Xa levels after fixed dose prophylaxis with enoxaparin after orthopedic surgery. Thromb Res 1998;91:137–142.

    Article  CAS  PubMed  Google Scholar 

  26. Vogel P, Laing PC, Jeffrey RB. Deep venous thrombosis of the lower extremity: ultrasound evaluation. Radiology 1987;163:747–751.

    Article  CAS  PubMed  Google Scholar 

  27. Tapson VF. Pulmonary embolism—new diagnostic approaches. N Engl J Med 1997;336:1449–1451.

    Article  CAS  PubMed  Google Scholar 

  28. Blachere H, Latrabe V, Montaudon M. Pulmonary embolism revealed on helical CT angiography: comparison with ventilation-perfusion radionuclide lung scanning. Am J Roentgenol 2000:174:1041–1047.

    Article  CAS  Google Scholar 

  29. The PIOPED Investigators. Value of the ventilation/ perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). JAMA 1990;263:2753–2759.

    Article  Google Scholar 

  30. Quader MA, Stump LS, Sumpio BE. Low molecular weight heparins: current use and indications. J Am Coll Surg 1998; 187:641–658.

    Article  CAS  PubMed  Google Scholar 

  31. Wilson SJ, Wilbur K, Burton E, Anderson DR. Effect of patient weight on the anticoagulant response to adjusted therapeutic dosage of low molecular weight heparin for the treatment of venous thromboembolism. Haemostasis 2001; 31:42–48.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Bonanomi, G., Hamad, G., Bontempo, F.A. (2007). Venous Thrombosis and Pulmonary Embolism. In: Schauer, P.R., Schirmer, B.D., Brethauer, S.A. (eds) Minimally Invasive Bariatric Surgery. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68062-0_47

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-68062-0_47

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-68058-3

  • Online ISBN: 978-0-387-68062-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics