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Tip Functionalization: Applications to Chemical Force Spectroscopy

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Handbook of Molecular Force Spectroscopy

Adhesion events in chemistry, biology, and material science occur through intermolecular interactions between distinct chemical functionalities. Chemical force spectroscopy has recently emerged as a powerful and versatile tool for the quantitative characterization of these molecular forces. Based on atomic force microscopy (AFM), chemical force spectroscopy relies on the modification of probe tips as a means of introducing chemical specificity into force measurements. In practice, a chemically modified tip is brought into contact with a substrate of specific functionality and as the tip is withdrawn, the interaction force between the functionalized tip and substrate is measured.

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Authors and Affiliations

  1. Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, L-454, 7000 East Ave, Livermore, CA, 94550, USA

    Craig D. Blanchette

  2. Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, L-231, 7000 East Ave, Livermore, CA, 94550, USA

    Albert Loui

  3. Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, L-231, 7000 East Ave, Livermore, CA, 94550, USA

    Timothy V. Ratto

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  1. Craig D. Blanchette
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  2. Albert Loui
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  3. Timothy V. Ratto
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Editors and Affiliations

  1. Chemistry, Materials and Life Sciences Directorate, Lawerence Livermore National Laboratory, Livermore, CA, USA

    Aleksandr Noy

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Blanchette, C.D., Loui, A., Ratto, T.V. (2008). Tip Functionalization: Applications to Chemical Force Spectroscopy. In: Noy, A. (eds) Handbook of Molecular Force Spectroscopy. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-49989-5_7

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