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Advanced Head and Neck Malignancy

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Evidence-Based Otolaryngology

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Abstract

A computerized Ovid search of MEDLINE 1966-January 2006 was performed. The terms “postoperative therapy,” “adjuvant therapy,” and “head and neck cancer” were exploded and the resulting articles were cross-referenced, yielding 7643 articles limited to “human” and “English language.” These articles or abstracts were then reviewed to identify those that met the following inclusion criteria: 1) patient population with operable squamous cell carcinoma of the head and neck (SCCHN) with highrisk features, 2) intervention with a postoperative experimental arm (postoperative cisplatin with radiotherapy) versus a standard therapy arm (postoperative radiotherapy alone), 3) primary outcome measured in terms of progression- or disease-free survival, overall survival (OS), or locoregional (LR) control. The references of these articles were reviewed and manually cross-checked to ensure all applicable literature was included. This process yielded three randomized controlled trials (RCTs), a detailed analysis of which is presented below.

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Author information

Authors and Affiliations

  1. Dana-Farber Cancer Institute, Boston, MA, USA

    Lori Wirth MD

  2. Department of Otolaryngology, Johns Hopkins University, Baltimore, MD, USA

    Babar Sultan MD

  3. Head and Neck Medical Oncology, M.D. Anderson, Houston, TX, USA

    Merrill S. Kies MD (Professor)

Authors
  1. Lori Wirth MD
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  2. Babar Sultan MD
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  3. Merrill S. Kies MD
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Editor information

Editors and Affiliations

  1. Harvard Program in Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Jennifer J. Shin MD

  2. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Christopher J. Hartnick MD, MSE

  3. Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Gregory W. Randolph MD (Pediatric Otolaryngology) (Pediatric Otolaryngology)

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Wirth, L., Sultan, B., Kies, M.S. (2008). Advanced Head and Neck Malignancy. In: Shin, J.J., et al. Evidence-Based Otolaryngology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49979-6_32

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  • DOI: https://doi.org/10.1007/978-0-387-49979-6_32

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-24447-1

  • Online ISBN: 978-0-387-49979-6

  • eBook Packages: MedicineMedicine (R0)

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