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Prodrugs pp 1207–1219Cite as

Case Study: Clindamycin 2-Phosphate, A Prodrug of Clindamycin

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Part of the Biotechnology: Pharmaceutical Aspects book series (PHARMASP,volume V)

Abstract

The prodrug clindamycin 2-phosphate is rapidly converted in vivo to the parent drug, clindamycin, by phosphatase ester hydrolysis. Clindamycin is an antibacterial agent used orally in treating gram-positive infections, anaerobic infections, and methicillin-resistant staphlococcal and streptococcal infections. Clindamycin 2-phosphate, unlike clindamycin, is highly water soluble and does not produce pain upon injection.

Keywords

  • Benzyl Alcohol
  • Benzoyl Peroxide
  • Sodium Sulfosuccinate
  • Vaginal Cream
  • Lauroyl Sarcosinate

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Author information

Authors and Affiliations

  1. Pfizer Inc., Kalamazoo, MI

    W. Morozowich

  2. Bridge Organic Chemicals, Vicksburg, MI

    H. A. Karnes

Authors
  1. W. Morozowich
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  2. H. A. Karnes
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Editor information

Editors and Affiliations

  1. University of Kansas, Lawrence, KS, USA

    Valentino J. Stella & Ronald T. Borchardt & 

  2. Bristol-Myers Squibb Company, Princeton, NJ, USA

    Michael J. Hageman

  3. Gilead Sciences, Foster City, CA, USA

    Reza Oliyai

  4. Roche Palo Alto, LLC, Palo Alto, CA, USA

    Hans Maag

  5. Hoffmann-La Roche, Inc., Nutley, NJ, USA

    Jefferson W. Tilley

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© 2007 American Association of Pharmaceutical Scientists

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Morozowich, W., Karnes, H.A. (2007). Case Study: Clindamycin 2-Phosphate, A Prodrug of Clindamycin. In: Stella, V.J., Borchardt, R.T., Hageman, M.J., Oliyai, R., Maag, H., Tilley, J.W. (eds) Prodrugs. Biotechnology: Pharmaceutical Aspects, vol V. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49785-3_38

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