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Prodrugs of Amides, Imides and Other NH-acidic Compounds

  • Chapter
Prodrugs

Part of the book series: Biotechnology: Pharmaceutical Aspects ((PHARMASP,volume V))

Abstract

The term ‘NH-acidic compound,’ in the context of this chapter, refers to amides, carbamates, ureas, imides, and sulfonamides (Figure 1). However, the above term will not include amines, as they are discussed in a previous chapter. This chapter reviews various prodrug strategies for modifying the physical, chemical, and biochemical properties of NH-acidic compounds. Synthetic methodologies are not covered, as this information is readily available from the primary references cited.

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Authors and Affiliations

  1. Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey, 08543, USA

    Victor R. Guarino

  2. Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, 66047, USA

    Valentino J. Stella

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  1. Victor R. Guarino
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  2. Valentino J. Stella
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Editors and Affiliations

  1. University of Kansas, Lawrence, KS, USA

    Valentino J. Stella  & Ronald T. Borchardt  & 

  2. Bristol-Myers Squibb Company, Princeton, NJ, USA

    Michael J. Hageman

  3. Gilead Sciences, Foster City, CA, USA

    Reza Oliyai

  4. Roche Palo Alto, LLC, Palo Alto, CA, USA

    Hans Maag

  5. Hoffmann-La Roche, Inc., Nutley, NJ, USA

    Jefferson W. Tilley

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Guarino, V.R., Stella, V.J. (2007). Prodrugs of Amides, Imides and Other NH-acidic Compounds. In: Stella, V.J., Borchardt, R.T., Hageman, M.J., Oliyai, R., Maag, H., Tilley, J.W. (eds) Prodrugs. Biotechnology: Pharmaceutical Aspects, vol V. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49785-3_23

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