Influenza Viral Infection: Stress-induced Modulation of Innate Resistance and Adaptive Immunity
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If you believe what you read in the newspapers, the world is poised for a pandemic. The scourge is likely to be infection with the influenza A virus. Although there may be some doubt concerning these cataclysmic predictions, they are based on solid epidemiological and historical data. It is well documented that during the past several centuries, an influenza virus pandemic has raced through the human population every 20–40 years or so. In 1918–1919, a pandemic due to influenza virus infected one out of every five humans. This “Spanish Flu,” which was also known as “La Grippe,” is estimated to have killed more than 30 million people in less than 2 years (Mills et al., 2004). To put this in perspective, this influenza pandemic killed one out of every four soldiers that died during World War I (Oxford et al., 2005). Luckily, there has not been a repeat of the 1918–1919 pandemic. However, recent events such as the emergence of the avian influenza that is currently causing mortality in Asia may signal the evolution of a new, highly virulent influenza virus that might cause a serious worldwide influenza epidemic.
KeywordsNatural Killer Natural Killer Cell Drain Lymph Node Restraint Stress Follicular Dendritic Cell
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