Abstract
Muscarinic acetylcholine (ACh) receptors (mAChRs) are members of the 7 transmembranespanning, guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. There are 5 subtypes of mAChRs, and these mediate the majority of the actions of ACh in both the central nervous system (CNS) and the periphery. For example, peripheral mAChR activation results in a reduction in heart rate and vasodilatation of vascular beds, increases in exocrine secretions from sweat and lacrimal glands, and contraction of smooth muscle in the gastrointestinal tract, airways, ciliary body, and iris sphincter. All 5 subtypes of mAChRs are expressed in the CNS and are postulated to play a role in learning and memory, arousal, REM sleep, psychotic states, control of movement, thermoregulation, reward behaviors, and the generation of epileptic foci. This chapter provides an overview of current knowledge regarding the structure, function, and pharmacology of the mAChRs, with a particular emphasis on their roles in the CNS. For a historical introduction, see Chapter 4 A-E.
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Christopoulos, A. (2007). Muscarinic Acetylcholine Receptors in the Central Nervous System: Structure, Function, and Pharmacology. In: Karczmar, A.G. (eds) Exploring the Vertebrate Central Cholinergic Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-46526-5_5
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