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CARDIOPROTECTIVE EFFECTS OF CURCUMIN

  • Sumitra Miriyala
  • Manikandan Panchatcharam
  • Puvanakrishnan Rengarajulu
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 595)

Abstract

Curcumin, a major active component of turmeric, is extracted from the powdered dry rhizome of Curcuma longa Linn (Zingiberaceae) and it has been used for centuries in indigenous medicine.We have shownthat curcumin has a protective role against myocardial necrosis in rats. The antioxidant activity of curcumin could be attributed to the phenolic and methoxy groups in conjunction with the 1,3-diketone-conjugated diene system, for scavenging of the oxygen radicals. In addition, curcumin is shown to enhance the activities of detoxifying enzymes such as glutathione-S-transferase in vivo. We have also shown that oxygen free radicals exacerbate cardiac damage and curcumin induces cardioprotective effect and it also inhibits free-radical generation in myocardial ischemia in rats.

Keywords

Platelet Aggregation Cardioprotective Effect Arterioscler Thromb Vasc Biol Caffeic Acid Phenethyl Ester Curcuma Longa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer 2007

Authors and Affiliations

  • Sumitra Miriyala
  • Manikandan Panchatcharam
  • Puvanakrishnan Rengarajulu

There are no affiliations available

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