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Related Methods for Three-Dimensional Imaging

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Handbook Of Biological Confocal Microscopy

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Abstract

The ability of confocal laser-scanning microscopy to collect stacks of optical sections has made three-dimensional (volumetric) imaging a standard analytical tool in experimental cell and developmental biology. Parallel developments in deconvolution techniques, especially as computational power increased and costs decreased, offered tools to make three-dimensional (3D) imaging from widefield as well as confocal microscopes possible. Despite the high spatial resolution provided by these 3D methods, they all suffer from a common limitation: light scattering in the specimen limits them to operating in the outer few hundred micrometers of the specimen.

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Authors and Affiliations

  1. California Institute of Technology, Pasadena, California, 91125

    J. Michael Tyszka, Seth W. Ruffins & Scott E. Fraser

  2. University of Wisconsin, Madison, Wisconsin, 53706

    Jamey P. Weichert

  3. ORNL and CTI-Concorde Microsystems, Knoxville, Tennessee, 37932

    Michael J. Paulus

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  1. J. Michael Tyszka
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  2. Seth W. Ruffins
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  3. Jamey P. Weichert
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  4. Michael J. Paulus
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  5. Scott E. Fraser
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  1. Department of Zoology, University of Wisconsin, Madison, WI, 53706, USA

    James B. Pawley

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Tyszka, J.M., Ruffins, S.W., Weichert, J.P., Paulus, M.J., Fraser, S.E. (2006). Related Methods for Three-Dimensional Imaging. In: Pawley, J. (eds) Handbook Of Biological Confocal Microscopy. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-45524-2_34

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