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GtBP Family Proteins pp 28–38Cite as

CtBP and Hematopoietic Transcriptional Regulators

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Abstract

The C-terminal binding proteins (CtBPs) are ubiquitous corepressors that recruit histone-modifying enzymes to a variety of sequence specific DNA-binding proteins and other transcriptional regulators. CtBPs appear to play an important role in mediating repression and transforming activities of a variety of hematopoietic transcription factors such as Basic Krüppel-like Factor/Krüppel-like Factor 3 (BKLF/KLF3), Friend of GATA (FOG), Evi-1 and members of the Ikaros family. Mice lacking CtBPs die during embryonic development and exhibit defects in a wide range of developmental processes, including aberrant heart formation and absence of blood vessels in the yolk sac. The ongoing identification of repressed target genes and interacting transcriptional partners will help to unravel the contributions of CtBP proteins to hematopoiesis.

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Authors and Affiliations

  1. School of Molecular and Microbial Biosciences, University of Sydney, 2006, New South Wales, Australia

    Alexis Verger & Merlin Crossley

  2. Centre for Thrombosis and Vascular Research School of Medical Sciences and Department of Medicine St. George Clinical School, University of New South Wales, New South Wales, Australia

    Jose Perdomo

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  1. Alexis Verger
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  2. Jose Perdomo
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  3. Merlin Crossley
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Correspondence to Alexis Verger .

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Verger, A., Perdomo, J., Crossley, M. (2007). CtBP and Hematopoietic Transcriptional Regulators. In: GtBP Family Proteins. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39973-7_3

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