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GtBP Family Proteins pp 18–27Cite as

Transcriptional Repression by the CtBP Corepressor in Drosophila

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Abstract

Transcriptional repression is essential for patterning gene expression in the early Drosophila embryo. Biochemical and genetic studies on Drosophila C-terminal binding protein (dCtBP) have provided solid evidence that dCtBP acts as a corepressor for several transcriptional repressors. Similarly to mammalian CtBPs, dCtBP interacts with a short peptide motif, PxDLS, or related motifs. It appears that dCtBP is essential for short-range transcriptional repression in the early embryo. In contrast, it has been recendy reported that dCtBP participates in Polycomb-mediated long-range repression. In this chapter, we will review how the dCtBP corepressor functions, from the biochemical, developmental, and genetic point of views.

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, A308, New York, New York, 10021, USA

    Hitoshi Aihara, Lorena Perrone & Yutaka Nibu

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  1. Hitoshi Aihara
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  2. Lorena Perrone
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  3. Yutaka Nibu
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Correspondence to Yutaka Nibu .

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Aihara, H., Perrone, L., Nibu, Y. (2007). Transcriptional Repression by the CtBP Corepressor in Drosophila . In: GtBP Family Proteins. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39973-7_2

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