Summary
A surprising new aspect of CtBP family proteins arose from the identification of a novel CtBP protein named RIBEYE.1 RIBEYE, which consists of a unique amino-terminal A-domain and a carboxy-terminal B-domain, largely identical to CtBP2, was discovered not as a nuclear protein but as a major component of synaptic ribbons in mammalian retina.1 Ribbon synapses are structurally specialized, tonically active chemical synapses, and are present, for example, in the sensory neurons of the retina and the inner ear.2,3 Recently, we identified also CtBPl, the founder member of the CtBP family,4 as an active zone component at conventional and ribbon synapses.5 The discovery of synaptic CtBP family members highlights that CtBP proteins serve more functions than previously envisioned.
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© 2007 Landes Bioscience and Springer Science+Business Media
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Dieck, S.t., Schmitz, F., Brandstätter, J.H. (2007). CtBPs as Synaptic Proteins. In: GtBP Family Proteins. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39973-7_11
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DOI: https://doi.org/10.1007/978-0-387-39973-7_11
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