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Shh and Gli Signalling and Development pp 137–146Cite as

Shh/Gli Signalling during Murine Lung Development

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Abstract

Murine lung development is a complex process regulated by many factors guiding a carefully orchestrated series of events leading to mature lung formation. Many developmental pathways have been implicated in governing proper lung formation. Most notably, the Shh/Gli pathway shown to be crucial to the development of numerous other organ systems, is an absolute requirement for correct lung formation. Many interactions between the Shh pathway and other fundamental lung signalling molecules such as fibroblast growth factor 10 (Fgf10) have presented themselves. While the specifics of these interactions have yet to be elucidated, the consequence of their actions is paramount in guiding lung development.

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Authors and Affiliations

  1. Program in Lung Biology Research, The Hospital for Sick Children Research Institute, Institute of Medical Sciences, University of Toronto, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada

    Martin Rutter & Martin Post

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  1. Martin Rutter
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  2. Martin Post
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© 2006 Landes Bioscience and Springer Science+Business Media

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Rutter, M., Post, M. (2006). Shh/Gli Signalling during Murine Lung Development. In: Shh and Gli Signalling and Development. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39957-7_13

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