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Heat Shock Proteins in Multiple Sclerosis

  • Celia F. BrosnanEmail author
  • Luca Battistini
  • Krzysztof Selmaj
Part of the Neuroscience Intelligence Unit book series

Abstract

In this review, we have addressed the possible contribution of heat shock proteins (HSP) to the pathogenesis of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system (CNS). A particular focus of the review is on the families of HSP27, HSP60 and HSP70 because there is good evidence for both RNA and protein that expression levels of these HSP are altered in lesioned areas of the CNS. Using a variety of different approaches, the data support a role for these HSP in the generation of the immune response, particularly in the more chronic phases of the disease process. In addition, we review evidence supporting a protective role for these HSP in the injured CNS. This dual role of HSP makes an analysis of their effects in degenerative CNS diseases difficult to determine with certainty. Nevertheless, ongoing data are persuasive that this remains an important area of research that is likely to continue to contribute to our understanding of disease pathogenesis in MS.

Keywords

Multiple Sclerosis Heat Shock Protein Experimental Autoimmune Encephalomyelitis Myelin Basic Protein Small Heat Shock Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  • Celia F. Brosnan
    • 1
    Email author
  • Luca Battistini
    • 2
  • Krzysztof Selmaj
    • 3
  1. 1.Department of PathologyAlbert Einstein College of MedicineBronxUSA
  2. 2.Neuroimmmunology Unit European Center for Brain ResearchSanta Lucia FoundationRomeItaly
  3. 3.Department of NeurologyMedical University of LodzLodzPoland

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