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Rab Domains on Endosomes

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Book cover Endosomes

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

Small GTPases of the Rab family have been long recognized to be key regulators of membrane trafficking. However, recent studies have uncovered their more fundamental role as determinants of organelle biogenesis and maintenance in all cells. Rab proteins acting in the endocytic pathway were shown to occupy nonoverlapping, morphologically and biochemically distinct domains on membranes of endosomes. Molecular characterization of Rab5 and its effectors revealed basic principles by which this GTPase mediates local changes in membrane structure and function, thus organizing a specific domain on early endosomes. Rab domains on endosomes appear to coordinate multiple functions related to membrane trafficking, organelle motility and signal transduction and are dynamically linked through the activity of bivalent Rab effectors. The concept of Rab proteins acting as membrane organizers provides a framework explaining the biogenesis of endocytic organelles composed of separate but functionally coupled domains which are arranged in a dynamic fashion.

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  1. International Institute of Molecular and Cell Biology, Ks. Trojdena 4, 02-109, Warsaw, Poland

    Marta Miaczynska

  2. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse, Dresden, Germany

    Marino Zerial

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Miaczynska, M., Zerial, M. (2006). Rab Domains on Endosomes. In: Endosomes. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39951-5_3

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