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Toxins in the Endosomes

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Book cover Endosomes

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Many bacteria owe their virulence to the production of protein toxins. These proteins usually play an important role in permitting the bacteria to successfully spread in the host and cause infection. With the exception of poreforming toxins and lipases, all toxins need to be endocytosed by the host cell to perform their toxin action. In the recent years, the increased knowledge of how toxins enter the cells and reach the cytoplasm have highlighted their ability to exploit, in its finest details, the membrane-trafficking systems of their hosts. In this chapter, based on selected examples we will review how toxins use the host endosomal system to reach their targets.

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Authors and Affiliations

  1. Department of Microbiology and Molecular Medicine, University of Geneva, 1 rue Michel Servet, 1211, Geneva 4, Switzerland

    Núria Reig & F. Gisou van der Goot

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  1. Núria Reig
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  2. F. Gisou van der Goot
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© 2006 Landes Bioscience and Springer Science+Business Media

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Reig, N., van der Goot, F.G. (2006). Toxins in the Endosomes. In: Endosomes. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39951-5_12

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