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Gastroenterologic and Hepatic Diseases

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Immunogenetics of Autoimmune Disease

Part of the book series: Medical Intelligence Unit ((MIUN))

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Abstract

Celiac disease, autoimmune hepatitis (AIH), and the inflammatory bowel diseases (IBDs), Crohn’s disease and ulcerative colitis (UC), are chronic inflammatory diseases of unknown etiology. They are considered complex genetic diseases because both inherited and environmental influences appear to be important in determining risk Complex genetic diseases are more common than Mendelian diseases in the population. Prevalence ranges for AIH, IBD and celiac disease are given in Table 1. Generally, accepted average prevalences are 1 in 1,000 persons for Crohn’s disease and UC, and 3 in 1,000 for celiac disease. However, the prevalence rate of Crohn’s, UC and celiac disease are much lower in some populations (e.g., 1.25 in 100,000 for Crohn’s disease in Hong Kong1). The average prevalence of AIH is 10-fold lower at 1 in 10,000.

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  1. Inflammatory Disease Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

    Marcela K. Tello-Ruiz, Emily C. Walsh & John D. Rioux

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Tello-Ruiz, M.K., Walsh, E.C., Rioux, J.D. (2006). Gastroenterologic and Hepatic Diseases. In: Immunogenetics of Autoimmune Disease. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-39926-3_7

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