Conceptualizing the Self-Nonself Discrimination by the Vertebrate Immune System

  • Melvin Cohn


A Preamble: In the end, biological phenomena are best understood in terms of evolution, which implies among other things, interactive selection on variants such that the selector and the selectee evolve as lineages [Hull et al. 2001]. The formulation of the concept should precede any attempt at modeling or simulation of any family of observations. The construction of a computer web around a random collection of facts is of marginal interest. Abstractions must be heuristic implying a testable output accompanied by a sharpening of the concept. This essay is an effort to conceptualize the most divisively discussed segment of immunology, namely, the Self-Nonself discrimination.


Ectopic Expression Developmental Time Associative Recognition Effector Class Thymic Epithelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Melvin Cohn
    • 1
    • 2
  1. 1.Conceptual Immunology GroupThe Salk Institute for Biological StudiesLa Jolla
  2. 2.Instituto Gulbenkian de CiênciaOeirasPortugal

Personalised recommendations