Abstract
Neural maps of the somatosensory periphery are characterized by their somatotopic organization, and whisker- and digit-specific patterning in rodents. While a variety of molecular guidance cues help set up the topographic axonal projections in the brain, activity-dependent interactions between pre- and postsynaptic elements play a key role in neural patterning. Here we review our and other groups’ analyses of the phenotypes of mice with various types of NMDA receptor (NMDAR) subunit mutations as they relate to the development and patterning of somatosensory pathways. Our recent studies on axonal and dendritic development in region specific NMDAR subunit NR1 knockout and transgenic rescue of global NR1 knockout mice show that NMDAR signaling is necessary for dendritic and axonal pruning and patterning. Further development of region and cell type-specific gene targeting strategies in mice will undoubtedly reveal cellular and molecular mechanisms that underlie the formation of patterned somatotopic maps and their plasticity.
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Erzurumlu, R.S., Iwasato, T. (2006). Patterning of the Somatosensory Maps with NMDA Receptors. In: Erzurumlu, R., Guido, W., Molnár, Z. (eds) Development and Plasticity in Sensory Thalamus and Cortex. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-38607-2_10
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