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Where It All Began: The Heritage of Radioimmunoguided Surgery

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Radioguided Surgery

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Abstract

In the mid-1970s, crucial advances in immunology led to widespread fascination with the development of radiolabeled antibodies for immunoscintigraphy of primary or secondary tumors. The availability of these radiolabeled tumor-seeking agents constituted the first step toward radioimmunoguided surgery, as pioneered by Martin et al. (1),(2) in patients with colorectal cancer. This chapter provides an overview of the evolution of the radioimmunoguided surgery system, explains its main technical aspects, and outlines its clinical applications.

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References

  1. Martin EW Jr, Tuttle SE, Rousseau M, et al. Radioimmunoguided surgery: intraoperative use of monoclonal antibody 17-1A in colorectal cancer. Hybridoma. 1986;5:S97–S108.

    PubMed  Google Scholar 

  2. Martin EW Jr, Mojzisik CM, Hinkle GH Jr, et al. Radioimmunoguided surgery using monoclonal antibody. Am J Surg. 1988;156:386–392.

    Article  PubMed  Google Scholar 

  3. Primus FJ, Wang RH, Goldenberg DM, et al. Localization of human GW-39 tumors in hamsters by radiolabeled heterospecific antibody to carcinoembryonic antigen. Cancer Res. 1973;33:2977–2982.

    CAS  PubMed  Google Scholar 

  4. Goldenberg DM, Preston DF, Primus FJ, et al. Photoscan localization of GW-39 tumors in hamsters using radiolabeled anticarcinoembryonic antigen immunoglobulin G. Cancer Res. 1974;34:1–9.

    CAS  PubMed  Google Scholar 

  5. Kohler G, Milstein C. Continuous cultures of fused secreting antibody of redefined specificity. Nature. 1975:256;495–497.

    Article  CAS  PubMed  Google Scholar 

  6. Colcher D, Hand PH, Nuti M, et al. A spectrum of monoclonal antibodies reactive with human mammary tumor cells. Proc Natl Acad Sci USA. 1981;78:3199–3203.

    Article  CAS  PubMed  Google Scholar 

  7. Stramignoni D, Bowen R, Atkinson BF, Schlom J. Differential reactivity of monoclonal antibodies with human colon adenocarcinomas and adenomas. Int J Cancer. 1983;31:543–552.

    Article  CAS  PubMed  Google Scholar 

  8. Moldofsky PJ, Sears HF, Mulhern CB Jr, et al. Detection of metastatic tumor in normal-sized retroperitoneal lymph nodes by monoclonal-antibody imaging. N Engl J Med. 1984;311:106–107.

    Article  CAS  PubMed  Google Scholar 

  9. Begent RH, Keep PA, Searle F, et al. Radioimmunolocalization and selection for surgery in recurrent colorectal cancer. Br J Surg. 1986;73:64–67.

    Article  CAS  PubMed  Google Scholar 

  10. Aitken DR, Hinkle GH, Thurston MO, et al. A gammadetecting probe for radioimmune detection of CEAproducing tumors. Successful experimental use and clinical case report. Dis Colon Rectum. 1984;27:279–282.

    Article  CAS  PubMed  Google Scholar 

  11. Martin DT, Aitken D, Thurston M, et al. Successful experimental use of a self-contained gamma detecting device. Curr Surg. 1984;41:193–194.

    CAS  PubMed  Google Scholar 

  12. Martin DT, Hinkle GH, Tuttle S, et al. Intraoperative radioimmunodetection of colorectal tumor with a hand-held radiation detector. Am J Surg. 1985;150:672–675.

    Article  CAS  PubMed  Google Scholar 

  13. Sickle-Santanello BJ, O’Dwyer PJ, Mojzisik C, et al. Radioimmuno guided surgery using the monoclonal antibody B72.3 in colorectal tumors. Dis Colon Rectum. 1987;30:761–764.

    Article  CAS  PubMed  Google Scholar 

  14. Molinolo A, Simpson JF, Thor A, et al. Enhanced tumor binding using immunohistochemical analyses by second generation anti-TAG-72 monoclonal antibody against monoclonal antibody B72.3 in human tissue. Cancer Res. 1990;50:1291–1298.

    CAS  PubMed  Google Scholar 

  15. Colcher D, Minelli MF, Roselli M, Muraro R, Simpson-Milenic D, Schlom J. Radioimmunolocalization of human carcinoma xenografts with B72.3 second generation monoclonal antibodies. Cancer Res. 1988;48:4597–4603.

    CAS  PubMed  Google Scholar 

  16. Arnold MW, Schneebaum S, Berens A, et al. Intraoperative detection of colorectal cancer with radioimmunoguided surgery and CC49, a second-generation monoclonal antibody. Ann Surg. 1992;216:627–632.

    Article  CAS  PubMed  Google Scholar 

  17. Arnold MW, Schneebaum S, Berens A, et al. Radioimmunoguided surgery challenges traditional decision making in patients with primary colorectal cancer. Surgery. 1992;112:624–629.

    CAS  PubMed  Google Scholar 

  18. Kim JA, Triozzi PL, Martin EW Jr. Radioimmunoguided surgery for colorectal cancer. Oncology (Williston Park, N. Y.). 1993;7:55–60; discussion 60, 63–64.

    Google Scholar 

  19. Goldenberg DM. Introduction to the Fourth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer. Cancer. 1994;S73:759–760.

    Article  Google Scholar 

  20. Greiner JW, Guadagni F, Roselli M, Ullmann CD, Nieroda C, Schlom J. Improved experimental radioimmunotherapy of colon xenografts by combining 131I-CC49 and interferon-gamma. Dis Colon Rectum. 1994;37:S100–S105.

    Article  CAS  PubMed  Google Scholar 

  21. Roselli M, Guadagni F, Buonomo O, et al. Systemic administration of recombinant interferon alfa in carcinoma patients upregulates the expression of the carcinomaassociated antigens tumor-associated glycoprotein-72 and carcinoembryonic antigen. J Clin Oncol. 1996;14:2031–2042.

    CAS  PubMed  Google Scholar 

  22. Roselli M, Buonomo O, Piazza A, et al. Novel clinical approaches in monoclonal antibody-based management in colorectal cancer patients: radioimmunoguided surgery and antigen augmentation. Semin Surg Oncol. 1998;15:254–262.

    Article  CAS  PubMed  Google Scholar 

  23. Badellino F. Radioimmunoguided surgery in Italy: 2 years of experience (1996–1998) [foreword]. Semin Colon Rectal Surg. 1998;15:203–204.

    Google Scholar 

  24. Di Carlo V, De Nardi P, Stella M, et al. Preoperative and intraoperative radioimmunodetection of cancer pretargeted by biotinylated monoclonal antibodies. Semin Surg Oncol. 1998;15:235–238.

    Article  PubMed  Google Scholar 

  25. Roselli M, Buonomo O, Piazza A, et al. Novel clinical approaches in monoclonal antibody-based management in colorectal cancer patients: radioimmunoguided surgery and antigen augmentation. Semin Surg Oncol. 1998;15:254–262.

    Article  CAS  PubMed  Google Scholar 

  26. Roselli M, Guadagni F, Buonomo O, et al. Intraoperative radioimmunolocalization of an anti-CEA MAB F(Ab’)2 (FO23C5) in CEA serum-negative colorectal cancer patients. Anticancer Res. 1996;16:883–889.

    CAS  PubMed  Google Scholar 

  27. Hutzell P, Kashmiri S, Colcher D, et al. Generation and characterization of a recombinant/chimeric B72.3 (human gamma 1). Cancer Res. 1991;51:181–189.

    CAS  PubMed  Google Scholar 

  28. Colcher D, Bird R, Roselli M, et al. In vivo tumor targeting of a recombinant single-chain antigen-binding protein. J Natl Cancer Inst. 1990;82:1191–1197.

    Article  CAS  PubMed  Google Scholar 

  29. Bertsch DJ, Burak WE Jr, Young DC, et al. Radioimmunoguided surgery system improves survival for patients with recurrent colorectal cancer. Surgery. 1995;118:634–638.

    Article  CAS  PubMed  Google Scholar 

  30. Bertsch DJ, Martin EW Jr. Radioimmunoguided surgery (RIGS) challenges the traditional of colorectal cancer surgery. Paper presented at: 48th Annual Cancer Symposium of the Society of Surgical Oncology; March 23–26, 1995; Boston.

    Google Scholar 

  31. Arnold MW. The radioimmunoguided diagnosis in surgery for colorectal cancer: introduction. Semin Colon Rectal Surg. 1995;6:183–184.

    Google Scholar 

  32. Thurston MO, Mojzisik CM. The radioimmunoguided diagnosis in surgery for colorectal cancer: history and development of radioimmunoguided surgery. Semin Colon Rectal Surg. 1995;6:185–191.

    Google Scholar 

  33. Petty LR, Arnold MW, Martin EW Jr. The radioimmunoguided diagnosis in surgery for colorectal cancer: colon cancer radioimmunoguided surgery technology: diagnosis and prognosis. Semin Colon Rectal Surg. 1995;6:198–201.

    Google Scholar 

  34. Kim JA. The radioimmunoguided diagnosis in surgery for colorectal cancer: observations on the immunologic basis of the radioimmunoguided surgery system. Semin Colon Rectal Surg. 1995;6:202–206.

    Google Scholar 

  35. Hitchock CL. The radioimmunoguided diagnosis in surgery for colorectal cancer: radioimmunoguided surgery and the staging of colorectal carcinoma. Semin Colon Rectal Surg. 1995;6:207–216.

    Google Scholar 

  36. Wang YO, Sun YE, Zhang JM, et al. Clinical practice of Tc99m-Peplomycin imaging and radioguided surgery for lung neoplasms. Ai Zheng. 2003;22:749–752.

    PubMed  Google Scholar 

  37. Gu J, Zhao J, Li Z, et al. Clinical application of radioimmunoguided surgery in colorectal cancer using 125I-labeled carcinoembryonic antigen-specific monoclonal antibody submucosally. Dis Colon Rectum. 2003;46:1659–1666.

    Article  PubMed  Google Scholar 

  38. Agnese DM, Abdessalam SF, Burak WE Jr, et al. Pilot study using a humanized CC49 monoclonal antibody (HuCC49DeltaCH2) to localize recurrent colorectal carcinoma. Ann Surg Oncol. 2004;11:197–202.

    Article  PubMed  Google Scholar 

  39. Xiao J, Horst S, Hinkle G, et al. Pharmacokinetics and clinical evaluation of 125I-radiolabeled humanized CC49 monoclonal antibody (HuCC49deltaC(H)2) in recurrent and metastatic colorectal cancer patients. Cancer Biother Radiopharm. 2005;20:16–26.

    Article  CAS  PubMed  Google Scholar 

  40. Kim JC, Hong HK, Roh SA, et al. Efficient targeting of gastric cancer cells using radiolabeled anti-carcinoembryonic antigen-specific T84.66 fragments in experimental radioimmunoguided surgery. Anticancer Res. 2004;24:663–670.

    CAS  PubMed  Google Scholar 

  41. Kim JC, Hong HK, Roh SA, et al. Preclinical application of radioimmunoguided surgery using anti-carcinoembryonic antigen biparatopic antibody in colon cancer. Eur Surg Res. 2005;37:36–44.

    Article  CAS  PubMed  Google Scholar 

  42. Krag D, Moffat F. Nuclear medicine and the surgeon. Lancet. 1999;354:1019–1022.

    Article  CAS  PubMed  Google Scholar 

  43. Buonomo O, Cabassi A, Guadagni F, et al. Radioguided surgery of early breast lesions. Anticancer Res. 2001;21:2091–2097.

    CAS  PubMed  Google Scholar 

  44. DeNardo SJ. Radioimmunodetection and therapy of breast cancer. Semin Nucl Med. 2005:35:143–151.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Surgical Oncology, National Institute for Cancer Research (IST), Genoa, Italy

    Fausto Badellino MD

  2. Department of Internal Medicine, Clinical Oncology, University of Rome Tor Vergata, Rome, Italy

    Mario Roselli MD

  3. Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy

    Marzio Perri MD & Giuliano Mariani MD

  4. Department of Laboratory Medicine and Advanced Biotechnologies, S. Raffaele IRCCS, Rome, Italy

    Fiorella Guadagni MD

Authors
  1. Fausto Badellino MD
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  2. Mario Roselli MD
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  3. Marzio Perri MD
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  4. Fiorella Guadagni MD
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  5. Giuliano Mariani MD
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Editor information

Editors and Affiliations

  1. Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy

    Giuliano Mariani MD

  2. John Wayne Cancer Institute, Saint John’s Health Center, Santa Monica, California, USA

    Armando E. Giuliano MD (Chief of Science and Medicine) (Chief of Science and Medicine)

  3. Nuclear Medicine Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    H. William Strauss MD

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Badellino, F., Roselli, M., Perri, M., Guadagni, F., Mariani, G. (2008). Where It All Began: The Heritage of Radioimmunoguided Surgery. In: Mariani, G., Giuliano, A.E., Strauss, H.W. (eds) Radioguided Surgery. Springer, New York, NY. https://doi.org/10.1007/978-0-387-38327-9_21

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  • DOI: https://doi.org/10.1007/978-0-387-38327-9_21

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-33684-8

  • Online ISBN: 978-0-387-38327-9

  • eBook Packages: MedicineMedicine (R0)

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