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Radioguided Surgery pp 172–183Cite as

Sentinel Lymph Node Biopsy in Thyroid Cancer

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Abstract

Intraoperative lymphatic mapping and sentinel lymph node dissection are based on the concept that tumor status of the sentinel lymph node—the first node in the regional nodal basin that drains a primary tumor—reflects the tumor status of that basin’s remaining lymph nodes (1). This technique has been extensively validated in patients with melanoma and breast cancer and has been investigated in other solid tumors, such as thyroid carcinoma (2)–(4). However, differentiated thyroid carcinoma (DTC) is perhaps the only tumor in the human body where the presence of locoregional nodal metastasis has no bearing on the patient’s long-term survival, and therefore the role of the lymph node surgery is debatable and controversial (5).

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Author information

Authors and Affiliations

  1. Nuclear Medicine Service, Policlinico Gemelli, Catholic University of the Sacred Heart, Rome, Italy

    Massimo Salvatori MD

  2. Nuclear Medicine Service, PET Center, S. Maria della Misericordia Hospital, Istituto Oncologico Veneto (IOV), Rovigo, Italy

    Domenico Rubello MD

  3. Department of Nuclear Medicine, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK

    Michael J. O’Doherty MD

  4. Department of Surgery, University of Padua, Padua, Italy

    Maria Rosa Pelizzo MD

  5. Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy

    Giuliano Mariani MD

Authors
  1. Massimo Salvatori MD
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  2. Domenico Rubello MD
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  3. Michael J. O’Doherty MD
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  4. Maria Rosa Pelizzo MD
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  5. Giuliano Mariani MD
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Editor information

Editors and Affiliations

  1. Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy

    Giuliano Mariani MD

  2. John Wayne Cancer Institute, Saint John’s Health Center, Santa Monica, California, USA

    Armando E. Giuliano MD (Chief of Science and Medicine) (Chief of Science and Medicine)

  3. Nuclear Medicine Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    H. William Strauss MD

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Salvatori, M., Rubello, D., O’Doherty, M.J., Pelizzo, M.R., Mariani, G. (2008). Sentinel Lymph Node Biopsy in Thyroid Cancer. In: Mariani, G., Giuliano, A.E., Strauss, H.W. (eds) Radioguided Surgery. Springer, New York, NY. https://doi.org/10.1007/978-0-387-38327-9_17

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  • DOI: https://doi.org/10.1007/978-0-387-38327-9_17

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