Skip to main content
SpringerLink
Log in

Imaging of Angiogenesis

  • Chapter
Cardiac PET and PET/CT Imaging

Abstract

Since recognition of the key role of angiogenic factors in tumor growth more than 3 decades ago, physiological and pathological vascular development has been implicated in a number of pathological states including inflammation (e.g., coronary atherosclerotic plaque), diabetic retinopathy, peripheral vascular disease, and ischemic heart disease.1

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fam NP, Verma S, Kutryk M, Stewart DJ. Clinician guide to angiogenesis. Circulation. 2003;108:2613–2618.

    Article  PubMed  Google Scholar 

  2. Sinusas AJ. Imaging of angiogenesis. J Nucl Cardiol. 2004;11:617–633.

    Article  PubMed  Google Scholar 

  3. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature. 2000;407:242–248.

    Article  PubMed  CAS  Google Scholar 

  4. Ito WD, Arras M, Scholz D, Winkler B, Htun P, Schaper W. Angiogenesis but not collateral growth is associated with ischemia after femoral artery occlusion. Am J Physiol. 1997; 273 (pt 2):H1255–H1265.

    PubMed  CAS  Google Scholar 

  5. Simons M. Angiogenesis: where do we stand now? Circulation. 2005;111:1556–1566.

    Article  PubMed  Google Scholar 

  6. Helisch A, Schaper W. Arteriogenesis: the development and growth of collateral arteries. Microcirculation. 2003;10:83–97.

    PubMed  Google Scholar 

  7. Brooks PC, Clark RA, Cheresh DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science. 1994;264:569–571.

    Article  PubMed  CAS  Google Scholar 

  8. Lee SH, Wolf PL, Escudero R, Deutsch R, Jamieson SW, Thistlethwaite PA. Early expression of angiogenesis factors in acute myocardial ischemia and infarction. N Engl J Med. 2000;342:626–633.

    Article  PubMed  CAS  Google Scholar 

  9. Papetti M, Herman IM. Mechanisms of normal and tumor-derived angiogenesis. Am J Physiol Cell Physiol. 2002;282:C947–C970.

    PubMed  CAS  Google Scholar 

  10. Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996;380:435–439.

    Article  PubMed  CAS  Google Scholar 

  11. Suri C, Jones PF, Patan S, et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell. 1996;87:1171–1180.

    Article  PubMed  CAS  Google Scholar 

  12. Kastrup J, Jorgensen E, Ruck A, et al. Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris. A randomized double-blind placebo-controlled study: the Euroinject One trial. J Am Coll Cardiol. 2005;45:982–988.

    Article  PubMed  CAS  Google Scholar 

  13. Nunn AD. The biology of technetium based hypoxic tissue localising compounds. In: Machulla H-J, ed. Imaging of Hypoxia. Dordrecht, The Netherlands: Kluwer Academic Publishers; 1999:19–45.

    Google Scholar 

  14. Sinusas A. The potential for myocardial imaging with hypoxia markers. Semin Nucl Med. 1999;29:330–338.

    Article  PubMed  CAS  Google Scholar 

  15. Martin GV, Caldwell JH, Graham MM, et al. Noninvasive detection of hypoxic myocardium using fluorine-18-fluoromisonidazole and positron emission tomography. J Nucl Med. 1992;33:2202–2208.

    PubMed  CAS  Google Scholar 

  16. Shelton ME, Dence CS, Hwang DR, Welch MJ, Bergmann SR. Myocardial kinetics of fluorine-18 misonidazole: a marker of hypoxic myocardium. J Nucl Med. 1989;30: 351–358.

    PubMed  CAS  Google Scholar 

  17. Shi CQ, Sinusas AJ, Dione DP, et al. Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia. J Nucl Med. 1995;36:1078–1086.

    PubMed  CAS  Google Scholar 

  18. Rumsey W, Patel B, Kuczynski B, et al. Comparison of two novel technetium agents for imaging ischemic myocardium. Circulation. 1995;92(suppl I):I–181.

    Google Scholar 

  19. Rumsey WL, Kuczynski B, Patel B, et al. SPECT imaging of ischemic myocardium using a technetium-99m-nitroimidazole ligand. J Nucl Med. 1995;36:1445–1450.

    PubMed  CAS  Google Scholar 

  20. Brack SS, Dinkelborg LM, Neri D. Molecular targeting of angiogenesis for imaging and therapy. Eur J Nucl Med Mol Imaging. 2004;31:1327–1341.

    Article  PubMed  Google Scholar 

  21. Chen X, Sievers E, Hou Y, et al. Integrin alpha v beta 3-targeted imaging of lung cancer. Neoplasia. 2005;7:271–279.

    Article  PubMed  CAS  Google Scholar 

  22. Haubner R, Weber WA, Beer AJ, et al. Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F] Galacto-RGD. PLoS Med. 2005;2:e70.

    Article  PubMed  Google Scholar 

  23. Hua J, Dobrucki LW, Sadeghi MM, et al. Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia. Circulation. 2005;111:3255–3260.

    Article  PubMed  CAS  Google Scholar 

  24. Leong-Poi H, Christiansen J, Heppner P, et al. Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression. Circulation. 2005;111:3248–3254.

    Article  PubMed  CAS  Google Scholar 

  25. Su H, Spinale FG, Dobrucki LW, et al. Evaluation of myocardial matrix metalloproteinase (MMP) mediated post-MI remodeling with a novel radiolabeled MMP inhibitor. J Nucl Cardiol. 2004;11:S20.

    Article  Google Scholar 

  26. Su H, Spinale F, Dobrucki L, et al. Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation. 2005;112: 3157–3167.

    Article  PubMed  CAS  Google Scholar 

  27. Leong-Poi H, Christiansen J, Klibanov AL, Kaul S, Lindner JR. Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins. Circulation. 2003;107:455–460.

    Article  PubMed  CAS  Google Scholar 

  28. Dayton PA, Pearson D, Clark J, et al. Ultrasonic analysis of peptideand antibody-targeted microbubble contrast agents for molecular imaging of alphavbeta3-expressing cells. Mol Imaging. 2004;3:125–134.

    Article  PubMed  CAS  Google Scholar 

  29. Blankenberg FG. Molecular imaging: The latest generation of contrast agents and tissue characterization techniques. J Cell Biochem. 2003;90:443–453.

    Article  PubMed  CAS  Google Scholar 

  30. Winter PM, Morawski AM, Caruthers SD, et al. Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles. Circulation. 2003;108:2270–2274.

    Article  PubMed  CAS  Google Scholar 

  31. Winter PM, Caruthers SD, Kassner A, et al. Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging. Cancer Res. 2003;63:5838–5843.

    PubMed  CAS  Google Scholar 

  32. Collingridge DR, Carroll VA, Glaser M, et al. The development of [(124)I]iodinatedVG76e: a novel tracer for imaging vascular endothelial growth factor in vivo using positron emission tomography. Cancer Res. 2002;62:5912–5919.

    PubMed  CAS  Google Scholar 

  33. Li S, Peck-Radosavljevic M, Koller E, et al. Characterization of (123)I-vascular endothelial growth factor-binding sites expressed on human tumour cells: possible implication for tumour scintigraphy. Int J Cancer. 2001;91:789–796.

    Article  PubMed  CAS  Google Scholar 

  34. Li S, Peck-Radosavljevic M, Kienast O, et al. Iodine-123-vascular endothelial growth factor-165 (123I-VEGF165). Biodistribution, safety and radiation dosimetry in patients with pancreatic carcinoma. Q J Nucl Med Mol Imaging. 2004;48:198–206.

    PubMed  CAS  Google Scholar 

  35. Lu E, Wagner WR, Schellenberger U, et al. Targeted in vivo labeling of receptors for vascular endothelial growth factor: approach to identification of ischemic tissue. Circulation. 2003;108:97–103.

    Article  PubMed  CAS  Google Scholar 

  36. Sipkins D, Cheresh D, Kazemi M, Nevin L, Bednarski M, Li K. Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med. 1998;4: 623–626.

    Article  PubMed  CAS  Google Scholar 

  37. Harris TD, Kalogeropoulos S, Nguyen T,et al. Design, synthesis, and evaluation of radiolabeled integrin alpha v beta 3 receptor antagonists for tumor imaging and radiotherapy. Cancer Biother Radiopharm. 2003;18:627–641.

    Article  PubMed  CAS  Google Scholar 

  38. Meoli DF, Sadeghi MM, Krassilnikova S, et al. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest. 2004;113:1684–1691.

    PubMed  CAS  Google Scholar 

  39. Johnson LL, Haubner R, Schofield L, Bouchard M, Schwaiger M. Radiolabeled RGD peptide to image angiogenesis in swine model of hibernating myocardium. Circulation. 2003;108(Suppl. S):405.

    Google Scholar 

  40. Lee KH, Jung KH, Song SH, et al. Radiolabeled RGD uptake and alphav integrin expression is enhanced in ischemic murine hindlimbs. J Nucl Med.2005;46:472–478.

    PubMed  CAS  Google Scholar 

  41. Blankenberg FG, Mandl S, Cao YA, et al. Tumor imaging using a standardized radiolabeled adapter protein docked to vascular endothelial growth factor. J Nucl Med. 2004;45:1373–1380.

    PubMed  CAS  Google Scholar 

  42. Lee PC, Kibbe MR, Schuchert MJ, et al. Nitric oxide induces angiogenesis and upregulates alpha(v)beta(3) integrin expression on endothelial cells. Microvasc Res. 2000;60: 269–280.

    Article  PubMed  CAS  Google Scholar 

  43. Haubner R, Wester H, Reuning U, et al. Radiolabeled alpha(v)beta3 integrin antagonists: a new class of tracers for tumor targeting. J Nucl Med. 1999;40:1061–1071.

    PubMed  CAS  Google Scholar 

  44. Lindsey ML, Escobar GP, Dobrucki LW, et al. Matrix metalloproteinase-9 gene deletion facilitates angiogenesis following myocardial infarction. Am J Physiol Heart Circ Physiol. 2006;290:H232–H239.

    Article  PubMed  CAS  Google Scholar 

  45. Sadeghi MM, Krassilnikova S, Zhang J, et al. Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo. Circulation. 2004;110:84–90.

    Article  PubMed  CAS  Google Scholar 

  46. Meoli D, Bourke B, Hu L, Brown L, Sinusas A. Regional hypoxia correlates with radiolabeled targeted markers of myocardiol angiogenesis in ischemic rat model. J Nucl Med. 2002;43(Suppl. S):8P.

    Google Scholar 

  47. Lewis MR. Radiolabeled RGD peptides move beyond cancer: PET imaging of delayedtype hypersensitivity reaction. J Nucl Med. 2005;46:2–4.

    PubMed  Google Scholar 

  48. Dzik-Jurasz A. Angiogenesis imaging in man: a personal view from the pharmaceutical industry. Br J Radiol. 2003;76(special number 1):S81–S82.

    Article  PubMed  Google Scholar 

  49. Isner JM, Losordo DW. Therapeutic angiogenesis for heart failure. Nat Med. 1999;5: 491–492.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA

    Lawrence W. Dobrucki PhD (Post-Doctoral Research Fellow)

  2. Yale University School of Medicine, Yale New Haven Hospital, New Haven, CT, USA

    Albert J. Sinusas MD (Professor of Medicine and Diagnostic Radiology, Director, Animal Research Labo-ratories, Section of Cardiovascular Medicine, Director, Cardiovascular Nuclear Imaging and Stress Laboratories)

Authors
  1. Lawrence W. Dobrucki PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Albert J. Sinusas MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Harvard Medical School, Boston, Massachusetts, USA

    Marcelo F. Di Carli MD (Chief of Nuclear Medicine, Co-Director of Cardiovascular Imaging, Brigham and Women’s Hospital, Associate Professor of Radiology and Medicine) (Chief of Nuclear Medicine, Co-Director of Cardiovascular Imaging, Brigham and Women’s Hospital, Associate Professor of Radiology and Medicine)

  2. Department of Radiology, Harvard Medical School, Boston, Massachusetts, USA

    Martin J. Lipton MD, FACR, FACC (Director of Education, Non-Invasive Imaging, Brigham and Women’s Hospital, Professor of Radiology) (Director of Education, Non-Invasive Imaging, Brigham and Women’s Hospital, Professor of Radiology)

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Dobrucki, L.W., Sinusas, A.J. (2007). Imaging of Angiogenesis. In: Di Carli, M.F., Lipton, M.J. (eds) Cardiac PET and PET/CT Imaging. Springer, New York, NY. https://doi.org/10.1007/978-0-387-38295-1_26

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-38295-1_26

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-35275-6

  • Online ISBN: 978-0-387-38295-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation