Developmental, Behavioral, and Physiological Phenotype of Cloned Mice

  • Kellie L. K. Tamashiro
  • Randall R. Sakai
  • Yukiko Yamazaki
  • Teruhiko Wakayama
  • Ryuzo Yanagimachi

Abstract

Cloning from adult somatic cells has been successful in at least ten species. Although generating viable cloned mammals from adult cells is technically feasible, prenatal and perinatal mortality is high and live cloned offspring have had health problems. This chapter summarizes the health consequences of cloning in mice and discusses possible mechanisms through which these conditions may arise. These studies have further significance as other assisted reproductive techniques (ART) also involve some of the same procedures used in cloning, and there are some reports that offspring generated by ART display aberrant phenotypes as well. At the moment, the long-term consequences of mammalian cloning remain poorly characterized. Data available thus far suggest that we should use this technology with great caution until numerous questions are addressed and answered.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Kellie L. K. Tamashiro
    • 1
    • 2
  • Randall R. Sakai
    • 2
  • Yukiko Yamazaki
    • 3
  • Teruhiko Wakayama
    • 3
    • 4
  • Ryuzo Yanagimachi
    • 3
  1. 1.Department of Psychiatry and Behavioral SciencesJohns Hopkins University, School of MedicineBaltimoreUSA
  2. 2.Neuroscience Program, Department of PsychiatryUniversity of Cincinnati, College of MedicineCincinnatiUSA
  3. 3.Institute for Biogenesis ResearchUniversity of Hawaii School of MedicineHonoluluUSA
  4. 4.Laboratory for Genomic Reprogramming, Center for Developmental BiologyRIKEN KobeKobeJapan

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