Skip to main content
SpringerLink
Log in

The Biology of the Presenilin Complexes

  • Chapter
Alzheimer’s Disease

  • 1684 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL (2005) Biochem Pharmacol 69:689–698.

    PubMed  CAS  Google Scholar 

  • Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G, Westaway D, George-Hyslop PS, Cordell B, Fraser P, De Strooper B (1999) J Cell Biol 147:277–294.

    PubMed  CAS  Google Scholar 

  • Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK (2004) EMBO J 23:2586–2596.

    PubMed  CAS  Google Scholar 

  • Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grunberg J, Haass C (1997) Genes Funct 1:149–159.

    PubMed  CAS  Google Scholar 

  • Beher D, Fricker M, Nadin A, Clarke EE, Wrigley JD, Li YM, Culvenor JG, Masters CL, Harrison T, Shearman MS (2003) Biochemistry 42:8133–8142.

    PubMed  CAS  Google Scholar 

  • Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS (1996) Neuron 17:1005–1013.

    PubMed  CAS  Google Scholar 

  • Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS (1997) Neuron 19:939–945.

    PubMed  CAS  Google Scholar 

  • Brown MS, Ye J, Rawson RB, Goldstein JL (2000) Cell 100:391–398.

    PubMed  CAS  Google Scholar 

  • Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR, Cumano A, Roux P, Black RA, Israel A (2000) Mol Cell 5:207–216.

    PubMed  CAS  Google Scholar 

  • Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C (1998) J Biol Chem 273:3205–3211.

    PubMed  CAS  Google Scholar 

  • Capell A, Kaether C, Edbauer D, Shirotani K, Merkl S, Steiner H, Haass C (2003) J Biol Chem 278:52519–52523.

    PubMed  CAS  Google Scholar 

  • Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, Haass C (2005) J Biol Chem 280:6471–6478.

    PubMed  CAS  Google Scholar 

  • Chartier-Harlin MC, Crawford F, Houlden H, Warren A, Hughes D, Fidani L, Goate A, Rossor M, Roques P, Hardy J, Mullan M (1991) Nature 353:844–846.

    PubMed  CAS  Google Scholar 

  • Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P (2003) J Biol Chem 278:19974–19979.

    PubMed  CAS  Google Scholar 

  • Chung HM, Struhl G (2001) Nat Cell Biol 3:1129–1132.

    PubMed  CAS  Google Scholar 

  • Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ (1997) Nat Med 3:67–72.

    PubMed  CAS  Google Scholar 

  • Clark RF, Hutton M, and Alzheimer’s Disease Collaborative Group (1995) Nat Genet 11:219–222.

    CAS  Google Scholar 

  • Crystal AS, Morais VA, Pierson TC, Pijak DS, Carlin D, Lee VM, Doms RW(2003) J Biol Chem 278:20117–20123.

    PubMed  CAS  Google Scholar 

  • Das C, Berezovska O, Diehl TS, Genet C, Buldyrev I, Tsai JY, Hyman BT, Wolfe MS (2003) J Am Chem Soc 125:11794–11795.

    PubMed  CAS  Google Scholar 

  • Davis JA, Naruse S, Chen H, Eckman C, Younkin S, Price DL, Borchelt DR, Sisodia SS, Wong PC (1998) Neuron 20, 603–609.

    PubMed  CAS  Google Scholar 

  • De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F (1997) J Biol Chem 272:3590–3598.

    PubMed  Google Scholar 

  • De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, von Figura K, Van Leuven F (1998) Nature 391:387–390.

    PubMed  Google Scholar 

  • De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R (1999) Nature 398:518–522.

    PubMed  Google Scholar 

  • Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS (1996) Neuron 17:1023–1030.

    PubMed  CAS  Google Scholar 

  • Donoviel DB, Hadjantonakis AK, Ikeda M, Zheng H, Hyslop PS, Bernstein A (1999) Genes Dev 13:2801–2810.

    PubMed  CAS  Google Scholar 

  • Dovey HF, John V, Anderson JP, Chen LZ, de Saint Andrieu P, Fang LY, Freedman SB, Folmer B, Goldbach E, Holsztynska EJ, Hu KL, Johnson-Wood KL, Kennedy SL, Kholodenko D, Knops JE, Latimer LH, Lee M, Liao Z, Lieberburg IM, Motter RN, Mutter LC, Nietz J, Quinn KP, Sacchi KL, Seubert PA, Shopp GM, Thorsett ED, Tung JS, Wu J, Yang S, Yin CT, Schenk DB, May PC, Altstiel LD, Bender MH, Boggs LN, Britton TC, Clemens JC, Czilli DL, Dieckman-McGinty DK, Droste JJ, Fuson KS, Gitter BD, Hyslop PA, Johnstone EM, Li WY, Little SP, Mabry TE, Miller FD, Audia JE (2001) J Neurochem 76:173–181.

    PubMed  CAS  Google Scholar 

  • Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-Tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S (1996) Nature 383:710–713.

    PubMed  CAS  Google Scholar 

  • Edbauer D, Winkler E, Haass C, Steiner H (2002) Proc Natl Acad Sci USA 99:8666–8671.

    PubMed  CAS  Google Scholar 

  • Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C (2003) Nat Cell Biol 5:486–488.

    PubMed  CAS  Google Scholar 

  • Edbauer D, Kaether C, Steiner H, Haass C (2004) J Biol Chem 279:37311–37315.

    PubMed  CAS  Google Scholar 

  • Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS (2000) Nat Cell Biol 2:428–434.

    PubMed  CAS  Google Scholar 

  • Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS (2002) Proc Natl Acad Sci USA 99:2720–2725.

    PubMed  CAS  Google Scholar 

  • Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W (2004) J Cell Biol 166:1041–1054.

    PubMed  CAS  Google Scholar 

  • Evin G, Canterford LD, Hoke DE, Sharples RA, Culvenor JG, Masters CL (2005) Biochemistry 44:4332–4341.

    PubMed  CAS  Google Scholar 

  • Feng R, Rampon C, Tang YP, Shrom D, Jin J, Kyin M, Sopher B, Miller MW, Ware CB, Martin GM, Kim SH, Langdon RB, Sisodia SS, Tsien JZ (2001) Neuron 32:911–926.

    PubMed  CAS  Google Scholar 

  • Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D (2002) Dev Cell 3:85–97.

    PubMed  CAS  Google Scholar 

  • Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cu W, Li HC, Schutte M, Gordon R, Holstein GR, Martinelli G, Mehta P, Friedrich VL Jr, Robakis NK (1999) Mol Cell 4:893–902.

    PubMed  CAS  Google Scholar 

  • Goate AM, Chartier-Harlin M-C, Mullan MJ, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Pericak-Vance M, Roses A, Williamson R, Rossor M, Owen M, Hardy J (1991) Nature 349:704–706.

    PubMed  CAS  Google Scholar 

  • Goutte C, Hepler W, Mickey KM, Priess JR (2000) Development 127:2481–2492.

    PubMed  CAS  Google Scholar 

  • Goutte C, Tsunozaki M, Hale VA, Priess JR (2002) Proc Natl Acad Sci USA 99:775–779.

    PubMed  CAS  Google Scholar 

  • Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI (2002) Biochemistry (Mosc) 67:826–835.

    PubMed  CAS  Google Scholar 

  • Gu Y, Chen F, Sanjo N, Kawarai T, Hasegawa H, Duthie M, Li W, Ruan X, Luthra A, Mount HT, Tandon A, Fraser PE, St George-Hyslop P (2003) J Biol Chem 278:7374–7380.

    PubMed  CAS  Google Scholar 

  • Haass C, Selkoe DJ (1993) Cell 75:1039–1042.

    PubMed  CAS  Google Scholar 

  • Hansson CA, Frykman S, Farmery MR, Tjernberg LO, Nilsberth C, Pursglove SE, Ito A, Winblad B, Cowburn RF, Thyberg J, Ankarcrona M (2004) J Biol Chem 279:51654–51660.

    PubMed  CAS  Google Scholar 

  • Hébert SS, Godin C, Tomiyama T, Mori H, Levesque G (2003) Biochem Biophys Res Commun 301:119–126.

    PubMed  Google Scholar 

  • Hébert SS, Serneels L, Dejaegere T, Horre K, Dabrowski M, Baert V, Annaert W, Hartmann D, De Strooper B (2004) Neurobiol Dis 17:260–272.

    PubMed  Google Scholar 

  • Henricson A, Kall L, Sonnhammer EL (2005) FEBS J 272:2727–2733.

    PubMed  CAS  Google Scholar 

  • Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, Van Leuven F, De Strooper B (1999) Proc Natl Acad Sci USA 96:11872–11877.

    PubMed  CAS  Google Scholar 

  • Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B (2000) Nat Cell Biol 2:461–462.

    PubMed  CAS  Google Scholar 

  • Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K, Mueller U, Annaert W, De Strooper B (2003) J Cell Sci 116:1127–1136.

    PubMed  CAS  Google Scholar 

  • Hu Y, Ye Y, Fortini ME (2002) Dev Cell 2:69–78.

    PubMed  CAS  Google Scholar 

  • Hu Y, Fortini ME (2003) J Cell Biol 161:685–690.

    PubMed  CAS  Google Scholar 

  • Johnston JA, Ward CL, Kopito RR (1998) J Cell Biol 143:1883–1898.

    PubMed  CAS  Google Scholar 

  • Jutras I, Laplante A, Boulais J, Brunet S, Thinakaran G, Desjardins M (2005) J Biol Chem 280:36310–36317.

    PubMed  CAS  Google Scholar 

  • Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C (2002) J Cell Biol 158:551–561.

    PubMed  CAS  Google Scholar 

  • Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C (2004) EMBO J 23:4738–4748.

    PubMed  CAS  Google Scholar 

  • Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H, Koo EH (2002) Cell 110:751–762.

    PubMed  CAS  Google Scholar 

  • Kim DY, Ingano LA, Kovacs DM (2002) J Biol Chem 277:49976–49981.

    PubMed  CAS  Google Scholar 

  • Kim SH, Yin YI, Li YM, Sisodia SS (2004) J Biol Chem 279:48615–48619.

    PubMed  CAS  Google Scholar 

  • Kim TW, Pettingell WH, Hallmark OG, Moir RD, Wasco W, Tanzi RE (1997) J Biol Chem 272:11006–11010.

    PubMed  CAS  Google Scholar 

  • Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ (2003) Proc Natl Acad Sci USA 100:6382–6387.

    PubMed  CAS  Google Scholar 

  • Kopan R, Goate A (2000) Genes Dev 14:2799–2806.

    PubMed  CAS  Google Scholar 

  • Kopan R, Ilagan MX (2004) Nat Rev Mol Cell Biol 5:499–504.

    PubMed  CAS  Google Scholar 

  • Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W (1996) Nat Med 2:224–229.

    PubMed  CAS  Google Scholar 

  • Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C (2005) J Biol Chem 280:39515–39523.

    PubMed  CAS  Google Scholar 

  • Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo EH, Golde TE (2005) Nat Med 11, 545–550.

    PubMed  CAS  Google Scholar 

  • LaFerla FM (2002) Nat Rev Neurosci 3:862–872.

    PubMed  CAS  Google Scholar 

  • Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM (2003) J Biol Chem 278:22475–22481.

    PubMed  CAS  Google Scholar 

  • Laudon H, Hansson EM, Melen K, Bergman A, Farmery MR, Winblad B, Lendahl U, von Heijne G, Naslund J (2005) J Biol Chem 280:35352–35360.

    PubMed  CAS  Google Scholar 

  • LaVoie MJ, Fraering PC, Ostaszewski BL, Ye W, Kimberly WT, Wolfe MS, Selkoe DJ (2003) J Biol Chem 278:37213–37222.

    PubMed  CAS  Google Scholar 

  • Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS (1996) J Neurosci 16:7513–7525.

    PubMed  CAS  Google Scholar 

  • Lee SF, Shah S, Li H, Yu C, Han W, Yu G (2002) J Biol Chem 277:45013–45019.

    PubMed  CAS  Google Scholar 

  • Lee SF, Shah S, Yu C, Wigley WC, Li H, Lim M, Pedersen K, Han W, Thomas P, Lundkvist J, Hao YH, Yu G (2004) J Biol Chem 279:4144–4152.

    PubMed  CAS  Google Scholar 

  • Leem JY, Vijayan S, Han P, Cai D, Machura M, Lopes KO, Veselits ML, Xu H, Thinakaran G (2002) J Biol Chem 277:19236–19240.

    PubMed  CAS  Google Scholar 

  • Leissring MA, Paul BA, Parker I, Cotman CW, LaFerla FM (1999a) J Neurochem 72:1061–1068.

    PubMed  CAS  Google Scholar 

  • Leissring MA, Parker I, LaFerla FM (1999b) J Biol Chem 274:32535–32538.

    PubMed  CAS  Google Scholar 

  • Leissring MA, Akbari Y, Fanger CM, Cahalan MD, Mattson MP, LaFerla FM (2000) J Cell Biol 149:793–798.

    PubMed  CAS  Google Scholar 

  • Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Muller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM (2002) Proc Natl Acad Sci USA 99:4697–4702.

    PubMed  CAS  Google Scholar 

  • Levesque G, Yu G, Nishimura M, Zhang DM, Levesque L, Yu H, Xu D, Liang Y, Rogaeva E, Ikeda M, Duthie M, Murgolo N, Wang L, VanderVere P, Bayne ML, Strader CD, Rommens JM, Fraser PE, St George-Hyslop P (1999) J Neurochem 72:999–1008.

    PubMed  CAS  Google Scholar 

  • Levitan D, Greenwald I (1995) Nature 377:351–354.

    PubMed  CAS  Google Scholar 

  • Levitan D, Doyle TG, Brousseau D, Lee MK, Thinakaran G, Slunt HH, Sisodia SS, Greenwald I (1996) Proc Natl Acad Sci USA 93:14940–14944.

    PubMed  CAS  Google Scholar 

  • Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu CE, Jondro PD, Schmidt SD, Wang K (1995) Science 269:973–977.

    PubMed  CAS  Google Scholar 

  • Levy-Lahad E, Poorkaj P, Wang K, Fu YH, Oshima J, Mulligan J, Schellenberg GD (1996) Genomics 34:198–204.

    PubMed  CAS  Google Scholar 

  • Li T, Ma G, Cai H, Price DL, Wong PC (2003) J Neurosci 23:3272–3277.

    PubMed  CAS  Google Scholar 

  • Li X, Greenwald I (1996) Neuron 17:1015–1021.

    PubMed  CAS  Google Scholar 

  • Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ (2000a) Nature 405:689–694.

    PubMed  CAS  Google Scholar 

  • Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, Shi XP, Yin KC, Shafer JA, Gardell SJ (2000b) Proc Natl Acad Sci USA 97:6138–6143.

    PubMed  CAS  Google Scholar 

  • Lichtenthaler SF, Beher D, Grimm HS, Wang R, Shearman MS, Masters CL, Beyreuther K (2002) Proc Natl Acad Sci USA 99:1365–1370.

    PubMed  CAS  Google Scholar 

  • Lleó A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, Frosch MP, Irizarry M, Hyman BT (2004) Nat Med 10:1065–1066.

    PubMed  Google Scholar 

  • Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah NG, Israel A (1998) Proc Natl Acad Sci USA 95:8108–8112.

    PubMed  CAS  Google Scholar 

  • Lopez-Schier H, St Johnston D (2002) Dev Cell 2:79–89.

    PubMed  CAS  Google Scholar 

  • Luo WJ, Wang H, Li H, Kim BS, Shah S, Lee HJ, Thinakaran G, Kim TW, Yu G, Xu H (2003) J Biol Chem 278:7850–7854.

    PubMed  CAS  Google Scholar 

  • Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK (2002) EMBO J 21:1948–1956.

    PubMed  CAS  Google Scholar 

  • Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK (2003) Cell 114:635–645.

    PubMed  CAS  Google Scholar 

  • Marjaux E, Hartmann D, De Strooper B (2004) Neuron 42:189–192.

    PubMed  CAS  Google Scholar 

  • Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D (2005) Proc Natl Acad Sci USA 102:8972–8977.

    PubMed  CAS  Google Scholar 

  • Meredith JE Jr, Wang Q, Mitchell TJ, Olson RE, Zaczek R, Stern AM, Seiffert D (2002) Biochem Biophys Res Commun 299:744–750.

    PubMed  CAS  Google Scholar 

  • Morais VA, Crystal AS, Pijak DS, Carlin D, Costa J, Lee VM, Doms RW (2003) J Biol Chem 278:43284–43291.

    PubMed  CAS  Google Scholar 

  • Mumm JS, Schroeter EH, Saxena MT, Griesemer A, Tian X, Pan DJ, Ray WJ, Kopan R (2000) Mol Cell 5:197–206.

    PubMed  CAS  Google Scholar 

  • Murrell J, Farlow M, Ghetti B, Benson MD (1991) Science 254:97–99.

    PubMed  CAS  Google Scholar 

  • Nagano O, Murakami D, Hartmann D, De Strooper B, Saftig P, Iwatsubo T, Nakajima M, Shinohara M, Saya H (2004) J Cell Biol 165:893–902.

    PubMed  CAS  Google Scholar 

  • Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS (1998) Neuron 21:1213–1221.

    PubMed  CAS  Google Scholar 

  • Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, van Noort M, Hui CC, Clevers H, Dotto GP, Radtke F (2003) Nat Genet 33:416–421.

    PubMed  CAS  Google Scholar 

  • Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T (2005) J Biol Chem 280:12967–12975.

    PubMed  CAS  Google Scholar 

  • Nishimura M, Yu G, Levesque G, Zhang DM, Ruel L, Chen F, Milman P, Holmes E, Liang Y, Kawarai T, Jo E, Supala A, Rogaeva E, Xu DM, Janus C, Levesque L, Bi Q, Duthie M, Rozmahel R, Mattila K, Lannfelt L, Westaway D, Mount HT, Woodgett J, Fraser PE, St George-Hyslop P (1999) Nat Med 5:164–169.

    PubMed  CAS  Google Scholar 

  • Pasternak SH, Bagshaw RD, Guiral M, Zhang S, Ackerley CA, Pak BJ, Callahan JW, Mahuran DJ (2003) J Biol Chem 278:26687–26694.

    PubMed  CAS  Google Scholar 

  • Perez-Tur J, Froelich S, Prihar G, Crook R, Baker M, Duff K, Wragg M, Busfield F, Lendon C, Clark RF, Roques P, Fuldner RA, Johnston JA, Cowburn R, Forsell C, Axelman K, Lilius L, Houlden H, Karran E, Roberts GW, Rossor M, Adams MD, Hardy J, Goate A, Lannfelt L, Hutton M (1995) Neuro Report 7:297–301.

    CAS  Google Scholar 

  • Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ (1997) Neurobiol Dis 3:325–337.

    PubMed  CAS  Google Scholar 

  • Ponting CP, Hutton M, Nyborg A, Baker M, Jansen K, Golde TE (2002) Hum Mol Genet 11:1037–1044.

    PubMed  CAS  Google Scholar 

  • Qian S, Jiang P, Guan XM, Singh G, Trumbauer ME, Yu H, Chen HY, Van de Ploeg LH, Zheng H (1998) Neuron 20:611–617.

    PubMed  CAS  Google Scholar 

  • Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL (1997) Mol Cell 1:47–57.

    PubMed  CAS  Google Scholar 

  • Rechards M, Xia W, Oorschot VM, Selkoe DJ, Klumperman J (2003) Traffic 4:553–565.

    PubMed  CAS  Google Scholar 

  • Rishton GM, Retz DM, Tempest PA, Novotny J, Kahn S, Treanor JJ, Lile JD, Citron M (2000) J Med Chem 43:2297–2299.

    PubMed  CAS  Google Scholar 

  • Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T (1995) Nature 376:775–778.

    PubMed  CAS  Google Scholar 

  • Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ 3rd, Kandel ER, Duff K, Kirkwood A, Shen J (2004) Neuron 42:23–36.

    PubMed  CAS  Google Scholar 

  • Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S (1996) Nat Med 2:864–870.

    PubMed  CAS  Google Scholar 

  • Schroeter EH, Kisslinger JA, Kopan R (1998) Nature 393:382–386.

    PubMed  CAS  Google Scholar 

  • Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, Shearman M, Kopan R (2003) Proc Natl Acad Sci USA 100:13075–13080.

    PubMed  CAS  Google Scholar 

  • Seiffert D, Bradley JD, Rominger CM, Rominger DH, Yang F, Meredith JE Jr, Wang Q, Roach AH, Thompson LA, Spitz SM, Higaki JN, Prakash SR, Combs AP, Copeland RA, Arneric SP, Hartig PR, Robertson DW, Cordell B, Stern AM, Olson RE, Zaczek R (2000) J Biol Chem 275:34086–34091.

    PubMed  CAS  Google Scholar 

  • Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK (2005) J Biol Chem 280:36007–36012.

    PubMed  CAS  Google Scholar 

  • Serneels L, Dejaegere T, Craessaerts K, Horre K, Jorissen E, Tousseyn T, Hebert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De Strooper B (2005) Proc Natl Acad Sci USA 102:1719–1724.

    PubMed  CAS  Google Scholar 

  • Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, Laplant Q, Ball H, Dann CE 3rd, Sudhof T, Yu G (2005) Cell 122:435–447.

    PubMed  CAS  Google Scholar 

  • Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S (1997) Cell 89:629–639.

    PubMed  CAS  Google Scholar 

  • Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HAR, Haines JL, Pericak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH (1995) Nature 375:754–760.

    PubMed  CAS  Google Scholar 

  • Shirotani K, Edbauer D, Prokop S, Haass C, Steiner H (2004) J Biol Chem 279:41340–41345.

    PubMed  CAS  Google Scholar 

  • Spasic D, Tolia A, Dillen K, Baert V, De Strooper B, Vrijens S, Annaert W (2006) J Biol Chem in press.

    Google Scholar 

  • Stahl B, Diehlmann A, Sudhof TC (1999) J Biol Chem 274:9141–9148.

    PubMed  CAS  Google Scholar 

  • Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C (1998) J Biol Chem 273:32322–32331.

    PubMed  CAS  Google Scholar 

  • Steiner H, Romig H, Grim MG, Philipp U, Pesold B, Citron M, Baumeister R, Haass C (1999a) J Biol Chem 274:7615–7618.

    PubMed  CAS  Google Scholar 

  • Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C (1999b) J Biol Chem 274:28669–28673.

    PubMed  CAS  Google Scholar 

  • Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C (2000) Nat Cell Biol 2:848–851.

    PubMed  CAS  Google Scholar 

  • Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C (2002) J Biol Chem 277:39062–39065.

    PubMed  CAS  Google Scholar 

  • Struhl G, Greenwald I (1999) Nature 398:522–525.

    PubMed  CAS  Google Scholar 

  • Struhl G, Adachi A (2000) Mol Cell 6:625–636.

    PubMed  CAS  Google Scholar 

  • Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T (2003) Nature 422:438–441.

    PubMed  CAS  Google Scholar 

  • Tarassishin L, Yin YI, Bassit B, Li YM (2004) Proc Natl Acad Sci USA 101:17050–17055.

    PubMed  CAS  Google Scholar 

  • Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland NG, Price DL, Sisodia SS (1996) Neuron 17:181–190.

    PubMed  CAS  Google Scholar 

  • Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grunberg J, Haass C, Iwatsubo T, Obata K (1997) Proc Natl Acad Sci USA 94:2025–2030.

    PubMed  CAS  Google Scholar 

  • Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T (1999) J Neurosci 19:10627–10634.

    PubMed  CAS  Google Scholar 

  • Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T (2001) J Biol Chem 276:33273–33281.

    PubMed  CAS  Google Scholar 

  • Urban S, Lee JR, Freeman M (2001) Cell 107:173–182.

    PubMed  CAS  Google Scholar 

  • Vito P, Lacana E, D’Adamio L (1996) Science 271:521–525.

    PubMed  CAS  Google Scholar 

  • Walker ES, Martinez M, Brunkan AL, Goate A (2005) J Neurochem 92:294–301.

    PubMed  CAS  Google Scholar 

  • Walter J, Capell A, Grunberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, Hyslop PS, Selkoe DJ, Haass C (1996) Mol Med 2:673–691.

    PubMed  CAS  Google Scholar 

  • Wang J, Brunkan AL, Hecimovic S, Walker E, Goate A (2004) Neurobiol Dis 15:654–666.

    PubMed  CAS  Google Scholar 

  • Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH (2001) Nature 414:212–216.

    PubMed  CAS  Google Scholar 

  • Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B (2002) Science 296:2215–2218.

    PubMed  CAS  Google Scholar 

  • Wilson CA, Murphy DD, Giasson BI, Zhang B, Trojanowski JQ, Lee VM (2004) J Cell Biol 165:335–346.

    PubMed  CAS  Google Scholar 

  • Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ (1999a) Nature 398:513–517.

    PubMed  CAS  Google Scholar 

  • Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ (1999b) Biochemistry 38:4720–4727.

    PubMed  CAS  Google Scholar 

  • Wolfe MS, Kopan R (2004) Science 305:1119–1123.

    PubMed  CAS  Google Scholar 

  • Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacana E, Sunderland T, Zhao B, Kusiak JW, Wasco W, D’Adamio L (1996) Science 274:1710–1713.

    PubMed  CAS  Google Scholar 

  • Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJ, Trumbauer ME, Chen HY, Price DL, Van der Ploeg LH, Sisodia SS (1997) Nature 387:288–292.

    PubMed  CAS  Google Scholar 

  • Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ (1998) Biochemistry 37:16465–16471.

    PubMed  CAS  Google Scholar 

  • Xia X, Qian S, Soriano S, Wu Y, Fletcher AM, Wang XJ, Koo EH, Wu X, Zheng H (2001) Proc Natl Acad Sci USA 98:10863–10868.

    PubMed  CAS  Google Scholar 

  • Ye Y, Lukinova N, Fortini ME (1999) Nature 398:525–529.

    PubMed  CAS  Google Scholar 

  • Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW (2000) Neuron 27:561–572.

    PubMed  CAS  Google Scholar 

  • Yu G, Chen F, Levesque G, Nishimura M, Zhang DM, Levesque L, Rogaeva E, Xu D, Liang Y, Duthie M, St George-Hyslop PH, Fraser PE (1998) J Biol Chem 273:16470–16475.

    PubMed  CAS  Google Scholar 

  • Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P (2000) Nature 407:48–54.

    PubMed  CAS  Google Scholar 

  • Yu H, Saura CA, Choi SY, Sun LD, Yang X, Handler M, Kawarabayashi T, Younkin L, Fedeles B, Wilson MA, Younkin S, Kandel ER, Kirkwood A, Shen J (2001) Neuron 31:713–726.

    PubMed  CAS  Google Scholar 

  • Zhou J, Liyanage U, Medina M, Ho C, Simmons AD, Lovett M, Kosik KS (1997) Neuroreport 8:1489–1494.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory for neuronal cell biology and gene transfer Center for Human Genetics, KU Leuven and VIB, Herestraat 49, 3000, Leuven, Belgium

    Tomoko Wakabayashi & Bart De Strooper

  2. Department of Neuropathology and Neuroscience Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

    Takeshi Iwatsubo

Authors
  1. Tomoko Wakabayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takeshi Iwatsubo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bart De Strooper
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The University of Chicago, IL

    Sangram S. Sisodia

  2. Massachusetts General Hospital and Harvard Medical School, USA

    Rudolph E. Tanzi

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Wakabayashi, T., Iwatsubo, T., De Strooper, B. (2007). The Biology of the Presenilin Complexes. In: Sisodia, S.S., Tanzi, R.E. (eds) Alzheimer’s Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-35135-3_3

Download citation

Publish with us

Policies and ethics

Search

Navigation