Modeling Tumors as Complex Biosystems: An Agent-Based Approach

  • Yuri Mansury
  • Thomas S. DeisboeckEmail author
Part of the Topics in Biomedical Engineering International Book Series book series (ITBE)


We argue that tumors behave as complex dynamic self-organizing and adaptive biosystems. In this chapter, we present a numerical agent-based model of malignant brain tumor cells in which both time and space are discrete yet environmental variables are treated as a continuum. Simulations of this multiscale algorithm allow us to investigate the molecular, microscopic, and multicellular patterns that emerge from various interactions among cells and between the cells and their environments.


Local Search Cellular Automaton Toxic Metabolite Tumor System Malignant Brain Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Inc. 2006

Authors and Affiliations

  1. 1.Complex Biosystems Modeling Laboratory, Harvard-MIT Athinoula A. Martinos Center for Biomedical ImagingMassachusetts General HospitalCharlestown
  2. 2.Complex Biosystems Modeling Laboratory, Harvard-MIT Athinoula A. Martinos Center for Biomedical ImagingMassachusetts General Hospital, East CNY-2301Charlestown

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