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Modeling Cancer as A Complex Adaptive System: Genetic Instability and Evolution

  • Kenneth J. PientaEmail author
Part of the Topics in Biomedical Engineering International Book Series book series (ITBE)

Abstract

Cancer is the second leading cause of death in the United States, claiming over 500,000 lives annually. While we now understand that cancer is a disease of genetic mutation, it is still difficult to describe how cancer arises from normal cells. Describing carcinogenesis in terms of a complex adaptive system reacting to the forces of Darwinian evolution gives a framework to understand tumorigenesis. This understanding is leading to new paradigms of cancer therapy, including multidisciplinary approaches to attack the cancer as a heterogeneous group of diseases as well as the development of aptamer molecular evolution techniques to design therapeutics to evolve as the cancer mutates.

Keywords

Cancer Cell Vascular Endothelial Growth Factor Modeling Cancer Genetic Instability Boolean Network 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Inc. 2006

Authors and Affiliations

  1. 1.University of Michigan Comprehensive Cancer CenterAnn Arbor

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