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Electronic Cell Environments: Combining Gene, Protein, and Metabolic Networks

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Complex Systems Science in Biomedicine

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Abstract

Whole-cell modeling is an emerging field of science that takes a systems view of the cell. The grand challenge is to understand, model, and simulate cellular complexity, and by extension, an organism. In this chapter we have tried to outline the raw material for modeling a cell, the advantages and limitations of various modeling strategies, the currently available tools, the biomedical applications, and the prospects for future growth in this field.

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Author information

Authors and Affiliations

  1. Bioinformatics Institute, Singapore

    P. Dhar

  2. Institute for Advanced Biosciences, Keio University, 5322 Endo, Fujisawa, Kanagawa, 252-8520, Japan

    M. Tomita

Authors
  1. P. Dhar
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  2. M. Tomita
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Correspondence to M. Tomita .

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Editors and Affiliations

  1. Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, East Bldg. 149, 13th Street, Charlestown, MA, 02129

    Thomas S. Deisboeck M.D. (Assistant Professor of Radiology (HMS, MGH, HST) and Director, Complex Biosystems Modeling Laboratory) (Assistant Professor of Radiology (HMS, MGH, HST) and Director, Complex Biosystems Modeling Laboratory)

  2. Dept. of Cardiothoracic Surgery, Drexel Univ. College of Medicine, 215 N. 15th Street, MS# 111, Philadelphia, PA, 19102-1192

    J. Yasha Kresh Ph.D., F.A.C.C. (Professor, Research Director, Professor of Medicine and Director) (Professor, Research Director, Professor of Medicine and Director)

  3. Cardiovascular Biophysics, Drexel Univ. College of Medicine, 215 N. 15th Street, MS# 111, Philadelphia, PA, 19102-1192

    J. Yasha Kresh Ph.D., F.A.C.C. (Professor, Research Director, Professor of Medicine and Director) (Professor, Research Director, Professor of Medicine and Director)

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Dhar, P., Tomita, M. (2006). Electronic Cell Environments: Combining Gene, Protein, and Metabolic Networks. In: Deisboeck, T.S., Kresh, J.Y. (eds) Complex Systems Science in Biomedicine. Topics in Biomedical Engineering International Book Series. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-33532-2_10

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