4. Conclusion
We demonstrate for the first time that TauT expression is upregulated during differentiation in C2C12 cells. In addition, taurine have a protective effect on muscle atrophy. Thus, taurine may be a therapeutic agent for cachexic state of diverse pathology.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
6. References
De Luca, A., Pierno, S., and Conte Camerino, D., 1996, Effect of taurine depletion on excitation-contraction coupling and Cl− conductance of rat skeletal muscle, Eur. J. Pharmacol. 296:215–222.
Fang, Y. Z., Yang, S., and Wu, G., 2002, Free radicals, antioxidants, and nutrition, Nutrition 18:872–879.
Guo, J., Li, R., Zhao, P., and Cheng, J., 2002, Effect of taurine in combination with electroacupuncture on neuronal damage following transient focal cerebral ischemia in rats, Acupunct. Electrother. Res. 27:129–136.
Huxtable, R. J., 1992, Physiological actions of taurine, Physiol. Rev. 72:101–163.
Ito, T., Fujio, Y., Hirata, M., Takatani, T., Matsuda, T., Muraoka, S., Takahashi, K., and Azuma, J., 2004, Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells, Biochem. J. 382:177–182.
Jagoe, R. T. and Goldberg, A. L., 2001, What do we really know about the ubiquitin-proteasome pathway in muscle atrophy? Curr. Opin. Clin. Nutr. Metab. Care. 4:183–190.
Jones, D. P., Miller, L. A., Dowling, C., and Chesney, R. W., 1991, Regulation of taurine transporter activity in LLC-PK1 cells: role of protein synthesis and protein kinase C activation, J. Am. Soc. Nephrol. 2:1021–1029.
Kendler, B. S., 1989, Taurine: an overview of its role in preventive medicine, Prev. Med. 18:79–100.
Lecker, S. H., Solomon, V., Mitch, W. E., and Goldberg, A. L., 1999, Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states, J. Nutr. 129:227S–237S.
McLaughlin, R., Bowler, D., Kelly, C. J., Kay, E., and Bouchier-Hayes, D., 2000, Taurine protects against early and late skeletal muscle dysfunction secondary to ischaemia reperfusion injury, Eur. J. Surg. 166:375–379.
Oz, E., Erbas, D., Gelir, E., and Aricioglu, A., 1999, Taurine and calcium interaction in protection of myocardium exposed to ischemic reperfusion injury, Gen. Pharmacol. 33:137–141.
Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., and Goldberg, A. L., 2004, Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy, Cell 117:399–412.
Schaffer, S., Takahashi, K., and Azuma, J., 2000, Role of osmoregulation in the actions of taurine, Amino Acids 19:527–546.
Shimizu, M., Mochizuki, T., and Satsu, H., 2003, Regulation of intestinal taurine transporter by cytokines, Adv. Exp. Med. Biol. 526:213–217.
Stitt, T. N., Drujan, D., Clarke, B. A., Panaro, F., Timofeyva, Y., Kline, W. O., Gonzalez, M., Yancopoulos, G. D., and Glass, D. J., 2004, The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors, Mol. Cell. 14:395–403.
Takatani, T., Takahashi, K., Uozumi, Y., Matsuda, T., Ito, T., Schaffer, S. W., Fujio, Y., and Azuma, J., 2004, Taurine prevents the ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes through Akt/caspase-9 pathway, Biochem. Biophys. Res. Commun. 316:484–489.
Warskulat, U., Flogel, U., Jacoby, C., Hartwig, H. G., Thewissen, M., Merx, M. W., Molojavyi, A., Heller-Stilb, B., Schrader, J., and Haussinger, D., 2004, Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised, FASEB J. 18:577–579.
Yaffe, D. and Saxel, O., 1977, Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle, Nature 270:725–727.
Yatabe, Y., Miyakawa, S., Miyazaki, T., Matsuzaki, Y., and Ochiai, N., 2003, Effects of taurine administration in rat skeletal muscles on exercise, J. Orthop. Sci. 8:415–419.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer Science+Business Media, LLC
About this paper
Cite this paper
Uozumi, Y. et al. (2006). Myogenic Induction of Taurine Transporter Prevents Dexamethasone-Induced Muscle Atrophy. In: Oja, S.S., Saransaari, P. (eds) Taurine 6. Advances in Experimental Medicine and Biology, vol 583. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-33504-9_29
Download citation
DOI: https://doi.org/10.1007/978-0-387-33504-9_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-32356-5
Online ISBN: 978-0-387-33504-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)