1. Abstract
The purpose of this study was to investigate the effect of dietary taurine supplementation on plasma and liver lipid concentrations and plasma and urine Ca, Mg, Se, Zn concentrations in alcohol-consuming (15% of energy/d) rats. Thirty-two male rats (Sprague-Dawley) were divided into 4 groups and fed experimental diets (nonalchol+ control diet, non-alcohol+taurine, alcohol+control diet, alcohol+taurine) for six weeks. The level of taurine supplementation was 1.5 g/100 g diet.
There were no significant differences in the body weight gain and total calorie intake between the control and alcohol groups, but the food efficiency ratio was higher in the control group. The concentrations of plasma total cholesterol, triglyceride, and HDLcholesterol were higher in the alcohol group, while the levels were apparently reduced in the groups fed taurine. Glutamate-oxaloacetate transaminase (GOT) and glutamatepyruvate transaminase (GPT) activities were not significantly influenced by alcohol (15% of energy) consumption and dietary taurine supplementation. The plasma concentrations of Ca, Mg, Se, and Zn were not affected by alcohol consumption or dietary taurine supplementation. Only the urinary excretion of Se significantly increased by alcohol consumption, which was decreased by dietary taurine supplementation. These results indicate that taurine exerted some beneficial effects on hypocholesterlemia, hypotriglyceridemia and urinary Se excretion caused by alcohol consumption.
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7. References
Bikle, D. D., 1993, Alcohol-induced bone disease, World Rev. Nutr. Diet 73:53–73.
Clark, J., Combs, G., Turnbull, B., Slate, E., Chalker, D., Chow, J., Davis, L., Glover, R., Dutta, S. K., Miller, P. A., Greenberg, L. B., Levander, O. A., 1983, Selenium and acute alcoholism, Am. J. Clin. Nutr. 38:713–718.
Folch, J., Less, M., and Sloane-Stanley, G. H., 1957, A simple method for the isolation and purification of total lipids from animal tissue, J. Biol. Chem. 226:497–509.
Friedewald, W. T., Levy, R. I., and Fredrickson, D. S., 1972, Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge, Clin. Chem. 18:499–502.
Felson, D. T., Zhang, Y., Hannan, M. T., Kannel, W. B., and Kiel, D. P., 1995, Alcohol intake and bone mineral density in elderly men and women, The Framingham Study, Am. Epidemiol. 142:485–492.
Gronbaek, M., Deis, A., Becker, U., Hein, H. O., Schnohr, P., Jensen, G., Borch-Johnsen, K., and Sorensen, T. I., 1998, Alcohol and mortality: is there a U-shaped relation in elderly people? Age Ageing 27:739–744.
Kalbfleisch, J. M., Lindemann, R. D., Ginn, H. E., and Smith, W. D., 1963, Effects of ethanol administration on urinary excretion of magnesium and other electrolytes in alcoholic and normal subjects, J. Clin. Invest. 42:1471.
Klein, R. F., Fausti, K. A., and Carlos, A. S., 1996, Ethanol inhibits human osteoblastic cell proliferation, Alcohol Clin. Exp. Res. 20:572–578.
Laitinen, K. and Välimäki, M., 1991, Alcohol and bone, Calcif Tissue Int. 49:S70–S73.
Levander, O. A., ed., 1987, Trace Elements in Human and Animal Nutrition, Academic Press, Orlando, FL, pp. 209–280.
McElduff, P. and Dobson, A. J., 1997, How much alcohol and how often? Population based case-control study of alcohol consumption and risk of a major coronary event, Br. Med. J. 314:1159–1164.
Park, T. S., Lee, K. S., and Um, Y. S., 1998, Dietary taurine supplementation reduces plasma and liver cholesterol and triglyceride concentrations in rats fed a high-cholesterol diet, Nutr. Res. 18:1559–1571.
Salonen, J. T., Alfthan, G., Huttunen, J. K., and Puska, P., 1984, Association between selenium status and the risk of cancer, Am. J. Epidemiol. 120:342–349.
Seelig, M. S. and Heggtveit, H. A., 1974, Magnesium interrelationships in ischemic heart disease: a review, Am. J. Clin. Nutr. 27:59–79.
Thomson, A., 1978, Alcohol and nutrition, Clin. Endocrinol. Metab. 7:405–428.
Turner, R. T., Greene, V. S., and Bell, N. H., 1987, Demonstration that ethanol inhibits bone matrix synthesis and mineralization in the rat, J. Bone Miner. Res. 2:61–66.
Turner, R. T., Kidder, L. S., Kennedy, A., Evans, G. L., and Sibonga, J. D., 2001, Moderate alcohol consumption suppresses bone turnover in adult female rats, J. Bone Miner. Res. 16:589–594.
Yan, C. C., Bravo, E., and Cantafora, A., 1993, Effect of taurine levels on liver lipid metabolism: an in vivo study in the rat, Proc. Soc. Exp. Biol. Med. 202:88–96.
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Choi, MJ., Kim, MJ., Chang, K.J. (2006). The Effect of Dietary Taurine Supplementation on Plasma and Liver Lipid Concentrations and Mineral Metabolism in Rats Fed Alcohol. In: Oja, S.S., Saransaari, P. (eds) Taurine 6. Advances in Experimental Medicine and Biology, vol 583. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-33504-9_26
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DOI: https://doi.org/10.1007/978-0-387-33504-9_26
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