1. Abstract
Taurine (2-aminoethanesulfonic acid) is known to attenuate the release of adrenomedullary catecholamines and ensuing hepatic glycogenolysis and hyperglycemia induced by pyridoxal in the rat. Using this animal model, the present study was undertaken to assess the impact that simple structural modifications of the taurine molecule might have on its antagonistic actions against PL. Removal of the amino group (ethanesulfonic acid) or shortening the carbon chain by one methylene (2- aminomethanesulfonic acid) raised the protective actions of taurine. While N-alkylation (N-methyltaurine) or replacement of the amino group by hydroxyl (isethionic acid) had a lowering effect, substituting a sulfhydryl group (2-mercaptoethanesulfonic acid) for the 2-amino group abolished all antagonistic properties associated with taurine. The sulfinic acid analog (hypotaurine) was equipotent with taurine, but the carboxylate isostere (β-alanine) was inactive. Propranolol, a nonspecific β-adrenoceptor antagonist, enhanced the antiglycogenolytic effect of taurine and of all structurally related compounds capable of attenuating the outflow of adrenal catecholamines elicited by pyridoxal.
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7. References
Dalton, K. and Dalton, M. J., 1987, Characteristics of pyridoxine overdose neuropathy syndrome, Acta Neurol. Scand. 76, 8–11.
Friedman, M. A., Resnick J. S., and Baer, R. L., 1986, Subepidermal vesicular dermatosis and sensory peripheral neuropathy caused by pyridoxine abuse, J. Am. Acad. Dermatol. 14:915–917.
Gleeson, R. A., Trapido-Rosenthal, H. G., and Carr, W. E. S., 1987, A taurine receptor model: taurine-sensitive olfactory cells in the lobster, in: The Biology of Taurine. Methods and Mechanisms, R. J. Huxtable, F. Franconi, and A. Giotti, eds., Plenum Press, New York, pp. 253–263.
Huxtable, R. J., 1989, Taurine in the central nervous system and the mammalian actions of taurine, Prog. Neurobiol. 32, 471–533.
Kendall. B. F., 1984, An investigation of selected toxic effects of pyridoxal and pyridoxine in the Sprague-Dawley rat, Ph.D. Thesis, St. John’s University, New York.
Keppler D. and Decker, D., 1974, Glycogen. Determination with amyloglucosidase, in: Methods of Enzymatic Analysis, vol. 3, H. U. Bergmeyer, ed., Academic Press, New York, pp. 1127–1131.
Krinke, G., Schaumburg, H.H., Spencer, P.S., Suter, J., Thomann P., and Hess, R., 1981, Pyridoxine megavitaminosis produces degeneration of peripheral sensory neurons (sensory neuropathy) in the dog, Neurotoxicology 2:13–24.
Kuriyama, K. and Nakagawa, K., 1976, Role of taurine in adrenal gland; a preventive effect on stress-induced release of catecholamines from chromaffin granules, in: Taurine, R. Huxtable and A. Barbeau, eds., Raven Press, New York, pp. 335–345.
Lau-Cam, C. A., Thadikonda, K. P., and Kendall, B. F., 1991, Stimulation of rat liver glycogenolysis by vitamin B6: a role for adrenal catecholamines, Res. Commun. Chem. Pathol. Pharmacol. 73:197–207.
Lewis, C. P. L., Cohen, G. M., and Smith, L. L., 1990, The identification and characterization of an uptake system for taurine into rat lung slices, Biochem. Pharmacol. 39:431–437.
Lombardini, J. B., 1985, Opposite effects of 2-aminoethanesulfonic acid (taurine) and aminomethanesulfonic acid on calcium uptake in rat retinal preparations, Eur. J. Pharmacol. 110:385–387.
Lombardini, J. B. and Liebowitz, S. M., 1990, Inhibitory and stimulatory effects of structural and conformational analogues of taurine on ATP-dependent calcium ion uptake in the rat retina: deductions concerning the conformation of taurine, in: Taurine: Functional Neurochemistry, Physiology, and Cardiology, H. Pasantes-Morales, D. L., Martin, W. Shain, and R. MartÍn del Rio, eds., Wiley-Liss New York, pp. 197–206.
Maturo, J. and Kulakowski, E. C., 1988, Taurine binding to the purified insulin receptor. Biochem. Pharmacol. 37:3755–3760.
Morra, M., Phillipszoon, H.D., D’Andrea, G., Cananzi, A.R., L’Erario, R., and Milone, F.F., 1993, Sensory and motor neuropathy caused by excessive ingestion of vitamin B6: a case report, Funct. Neurol. 8:429–432.
Nakagawa K. and Kuriyama, K., 1975, Effect of taurine on alteration in adrenal functions induced by stress. Jap. J. Pharmacol. 25:737–746.
Palmi, M., Frosini, M., and Sgaragli, G.P., 1987, Possible involvement of brain calcium in the action of taurine in mammalian thermoregulation, in: The Biology of Taurine. Methods and Mechanisms, R. J. Huxtable, F. Franconi, and A. Giotti, eds., Plenum Press, New York, pp. 237–244.
Palmi, M., Fusi, F., Youmbi, G., Frosini, M., Bianchi, L., Della Corte, L., Sgaragli G. P., and K. F. Tipton, 1996, Effects of taurine and structurally related analogues on Ca2+ uptake and respiration rate in rat liver mitochondria, in Taurine 2. Basic and Clinical Aspects, R. J. Huxtable, J. Azuma, K. Kuriyama, M. Nakagawa, and A. Baba, eds., Plenum Press, New York, pp. 117–124.
Parry, G. J. and Bredesen, D. E., 1985, Sensory neuropathy with low-dose pyridoxine, Neurology 35:1466–1468.
Perry, T. A., Weerasuriya, A., Mouton, P. R., Holloway, H. W., and Greig, N. H., 2004, Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy, Exp. Neurol. 190:133–144.
Petegnief, V., Lleu, P.L., Gupta, R. C., Bourguignon, J.-J., and Rebel, G., 1995, Taurine analog modulation of taurine uptake by two different mechanisms in cultured glial cells, Biochem. Pharmacol. 49:399–410.
Pokhrel, P. K. and Lau-Cam, C. A., 2000a, Protection by taurine and structurally related sulfur-containing compounds against erythrocyte membrane damage by hydrogen peroxide, in: Taurine 4. Taurine and Excitable Tissues, L. Della Corte, R. J. Huxtable, G. Sgaragli, and K. F. Tipton, eds., Kluwer Academic/Plenum Publishers, New York, pp. 411–429.
Pokhrel, P. K. and Lau-Cam, C. A., 2000b, In vitro and in vivo effects of taurine and structurally related sulfur-containing compounds against phenylhydrazine-induced oxidative damage to erythrocytes, in: Taurine 4. Taurine and Excitable Tissues, L. Della Corte, R. J. Huxtable, G. Sgaragli, and K. F. Tipton, eds., Kluwer Academic/ Plenum Publishers, New York, pp. 503–522.
Riley, V., 1960, Adaptation of orbital bleeding technic to rapid serial blood studies, Proc. Soc. Exp. Biol. Med. 104:751–754.
Schaeppi, U. and Krinke, G., 1982, Pyridoxine neuropathy: correlation of functional tests and neuropathology in beagle dogs treated with large doses of vitamin B6, Agents Actions 12:575–582.
Schaeppi, U. and Krinke, G., 1985, Differential vulnerability of 3 rapidly conducting somatosensory pathways in the dog with vitamin B6 neuropathy, Agents Actions 16:567–579.
Schaumburg, H., Kaplan, J., Windebank, A., Vick, N., Rasmus, S., Pleasure, D., and Brown, M. J., 1983, Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome, New Engl. J. Med. 309:445–448.
Sgaragli, G., Frosini, M., Palmi, M., Dixon, H. B. F., Desmond-Smith, N., Bianchi, L., and Della Corte, L., 1996, Role of taurine in thermoregulation and motor control, in: Taurine 2. Basic and Clinical Aspects, R. J. Huxtable, J. Azuma, K. Kuriyama, M. Nakagawa, and A. Baba, eds., Plenum Press, New York, pp. 527–535.
Wang, Y., Fice, D. S., and Yeung, P. K., 1999, A simple high-performance liquid chromatography assay for simultaneous determination of plasma norepinephrine, epinephrine, dopamine and 3,4-dihydroxyphenyl acetic acid, J. Pharm. Biomed. Anal. 21:519–525.
Waterston, J. A. and Gilligan, B. S., 1987, Pyridoxine neuropathy, Med. J. Aust. 146:640–642.
Welty, J. D., Read, W. O., and Byington, K. H., 1976, Comparison of amino-sulfonic acids as antiarrhythmic agents in dogs, in: Taurine, R. Huxtable and A. Barbeau, eds., Raven Press, New York, pp. 169–171.
Wietholter, H., Eckert, S., and Stevens, A., 1990, Measurement of atactic and paretic gait in neuropathies of rats based on analysis of walking tracks, J. Neurosci. Methods 32:199–205.
Williams, C. H., Dozier, S. E., Buzello, W., Gehrke, C. W., Wong, J. K., and Gerhardt, K. O., 1985, Plasma levels of norepinephrine and epinephrine during malignant hyperthermia in susceptible pigs. J. Chromatogr. 344:71–80.
Wollenberger, A., Ristau O., and Schoffa, G., 1960, A simple technic for extremely rapid freezing of large pieces of tissue. Pflugers Arch. Ges. Physiol. Menschen Tiere 270:399–412.
Wurtman, R. J., 1966, Catecholamines, Little Brown and Company, Boston, pp. 21–22.
Xu, Y., Sladky, J.T., and Brown, M.J., 1989, Dose-dependent expression of neuronopathy after experimental pyridoxine intoxication. Neurology 39:1077–1083.
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Lau-Cam, C.A., Patel, J.P. (2006). Comparison of the Effects of Taurine with Those of Related Sulfur-Containing Compounds on Pyridoxal-Induced Adrenomedullary Catecholamine Release and Glycogenolysis in the Rat. In: Oja, S.S., Saransaari, P. (eds) Taurine 6. Advances in Experimental Medicine and Biology, vol 583. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-33504-9_21
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