Differential role of N-Terminal Polyprotein Processing in Coronavirus Genome Replication and Minigenome Amplification

  • Carmen Galán
  • Luis Enjuanes
  • Fernando Almazán
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 581)


Plaque Morphology Virus Recovery Swine Testis Cell Conservative Amino Acid Change Human Coronavirus 229E 
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  1. 1.
    J. Ziebuhr, E. J. Snijder, and A. E. Gorbalenya, Virus-encoded proteinases and proteolytic processing in the Nidovirales, J. Gen. Virol. 81:853-879 (2000).PubMedGoogle Scholar
  2. 2.
    F. Almazán, J. M. González, Z. Pénzes, et al., Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome, Proc. Natl. Acad. Sci. USA 97, 5516-5521 (2000).CrossRefPubMedGoogle Scholar
  3. 3.
    A. Izeta, C. Smerdou, S. Alonso, et al., Replication and packaging of transmissible gastroenteritis coronavirus-derived synthetic minigenomes, J. Virol. 73:1535-1545 (1999).PubMedGoogle Scholar
  4. 4.
    J. Herold, A. E. Gorbalenya, V. Thiel, B. Schelle, and S. G. Siddell, Proteolytic processing at the amino terminus of human coronavirus 229E gene 1-encoded polyproteins: identification of a papain-like proteinase and its substrate, J. Virol. 72:910-918 (1998).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Carmen Galán
    • 1
  • Luis Enjuanes
    • 2
  • Fernando Almazán
    • 3
  1. 1.Centro Nacional de BiotecnologíaCSICSpain
  2. 2.Centro Nacional de BiotecnologíaCSICSpain
  3. 3.Centro Nacional de BiotecnologíaCSICSpain

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