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Molecular Mechanisms of Synaptogenesis pp 111–124Cite as

Role of Neuroligin Binding to Neurexins in Synaptic Organization

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1. Summary

The complex formed by the synaptic cell adhesion molecules neuroligin and β-neurexin has been implicated in synaptogenesis due to the molecular asymmetry of their heterophilic binding, reflecting the asymmetric nature of the synapse. During the past 5 years, their role in synapse formation has been explored in vitro, yielding exciting, though sometimes conflicting results. In this chapter, we focus on the biochemical and functional aspects of the neuroligin/β-neurexin complex, with an emphasis on the recent contributions coming from various cell culture approaches. In addition, we point out important unresolved issues with respect to their binding properties, their proposed function at excitatory versus inhibitory synapses, and their putative involvement in psychiatric diseases such as autism spectrum disorders.

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Author information

Authors and Affiliations

  1. Center for Physiology, Georg-August University Göttingen, Humboldtallee 23, 37073, Göttingen, Germany

    Richard Fairless, Carsten Reissner & Markus Missler

Authors
  1. Richard Fairless
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  2. Carsten Reissner
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  3. Markus Missler
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Editor information

Editors and Affiliations

  1. University Medical Center Hamburg-Eppendorf, 52 Martinistrasse, Hamburg, 20246, Germany

    Alexander Dityatev

  2. University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada, V6T 2A1

    Alaa El-Husseini

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Fairless, R., Reissner, C., Missler, M. (2006). Role of Neuroligin Binding to Neurexins in Synaptic Organization. In: Dityatev, A., El-Husseini, A. (eds) Molecular Mechanisms of Synaptogenesis. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-32562-0_8

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